{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:17:28Z","timestamp":1774271848551,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gonadoblastoma (GB) is an extremely rare mixed gonadal neoplasm, encountered in animals as well as humans. The tumour is typically reported in dysgenetic gonads of those suffering from disorders of sex development and bearing the Y chromosome. Here we highlight the first report of the co\u2010occurrence of an ovarian dysgerminoma\u2010inducing GB and anaplastic and complex carcinomas of distinct mammary glands in a phenotypically normal 12\u2010year\u2010old intact female Spitz lacking the Y chromosome. Germ cells of GB and dysgerminoma were negative for c\u2010kit but immunolabelled with SALL4, OCT\u20104, and E\u2010cadherin and aberrantly expressed WT\u20101. Sex cord\u2010stromal cells were immunoreactive for \u03b1\u2010inhibin, cytokeratin AE1\/AE3, and WT\u20101. Diffuse vimentin immunostaining was observed, while all cells were negative for high molecular weight cytokeratins. The Ki67 index was 30%. We describe the histopathological and immunohistochemical features of the index case and the polymerase chain reaction analysis of the\n                    <jats:italic>amelogenin (AMEL)<\/jats:italic>\n                    gene and provide a review of the literature. The mechanism of GB development may vary in patients with normal karyotypes and dysgenetic individuals. The WT\u20101 gene mutation may also play a role in the development of GB in the present case.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70470","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T04:40:21Z","timestamp":1750740021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010Occurrence of Ovarian Dysgerminoma\u2010Inducing Gonadoblastoma and Two Distinct Mammary Carcinomas in a Dog: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-3933","authenticated-orcid":false,"given":"Diba","family":"Golchin","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Pathology Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1785","authenticated-orcid":false,"given":"Farhang","family":"Sasani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Pathology Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-347X","authenticated-orcid":false,"given":"Saeed","family":"Farzad\u2010Mohajeri","sequence":"additional","affiliation":[{"name":"Department of Surgery and Radiology Faculty of Veterinary Medicine University of Tehran Tehran Iran"},{"name":"Institute of Biomedical Research, University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-9874","authenticated-orcid":false,"given":"Mohsen","family":"Tovhidifar","sequence":"additional","affiliation":[{"name":"Department of Surgery and Radiology Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-3721","authenticated-orcid":false,"given":"Iradj","family":"Ashrafi Tamai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Veterinary Medicine University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2004.tb00200.x"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"493","article-title":"Ovarian Carcinomatosis in a Dog Managed With Surgery and Intraperitoneal, Systemic, and Intrapleural Chemotherapy Utilizing Indwelling Pleural Access Ports","volume":"58","author":"Best M. 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