{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:54:02Z","timestamp":1775688842228,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018847","name":"Sel\u00e7uk University Research Foundation","doi-asserted-by":"publisher","award":["24202019"],"award-info":[{"award-number":["24202019"]}],"id":[{"id":"10.13039\/501100018847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Feline gingivostomatitis is a chronic disease of domestic cats characterised by inflammatory lesions along the gingiva and oral cavity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate oral vascular endothelial glycocalyx damage in gingivostomatitis caused by viral infections and other causes in cats using selected biomarkers of endothelial damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The material of this study consisted of 55 cats with gingivostomatitis and 15 healthy cats of different age, breed and sex. A total of 34 of 55 cats with gingivostomatitis had viral infections, whereas the cause of 21 cats could not be determined. Viral diseases were diagnosed by clinical findings and rapid antigen tests. Haemogram analysis was performed from blood samples. Serum endothelin\u20101 (ET\u20101), syndecan\u20101 (SDC\u20101), myeloperoxidase\u2010ANCA (MPO\u2010ANCA) and interleukin\u20106 (IL\u20106) biomarker concentrations were measured using feline\u2010specific commercial ELISA kits. Cats were treated medically for gingivostomatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although 49 cats recovered with the treatment, 6 cats died. There was a significant increase in serum ET\u20101 and SDC\u20101 concentrations and no difference in serum MPO\u2010ANCA and IL\u20106 concentrations in cats with gingivostomatitis. In addition, total leukocyte (WBC), granulocyte (GRA) and monocyte (MON) counts were increased in cats with gingivostomatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum levels of ET\u20101 and SDC\u20101, which are biomarkers of vascular endothelial damage, were increased in cats with gingivostomatitis. It was shown that vascular endothelial damage occurs in gingivostomatitis and that the biomarkers ET\u20101 and SDC\u20101 can be used to detect this damage and have a reliable diagnostic value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70525","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:22:19Z","timestamp":1753712539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Selected Endothelial Damage Biomarkers in the Determination of Endothelial Damage in Cats With Gingivostomatitis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5261-6825","authenticated-orcid":false,"given":"Saadet G\u00f6zde","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine Selcuk University  Konya 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