{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:20Z","timestamp":1772118920546,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020392","name":"Sylhet Agricultural University Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lumpy skin disease (LSD) is a transboundary viral pox disease that causes huge economic losses. The disease is in an epidemic situation, and the affected cattle show massive lesions and complexity, which is tough to treat; thus, a study was conducted to investigate the clinico\u2010haematological alterations of LSD\u2010affected cattle for adopting better pharmacotherapeutic management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A total of 36 LSD affected, and 8 healthy\/control cattle were examined and used for blood profiling. The control and affected cattle were categorized into four age groups consisting of nine cattle (Group A\u00a0=\u00a0under 1 year; Group B\u00a0=\u00a01 to 2 years; Group C\u00a0=\u00a02 to 3 years; and Group D\u00a0=\u00a0from 4 years up to 10 years) in each group and three disease periods of post infection (prodromal period, period of illness and period of decline) consist of each of 12 LSD affected cattle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical examination of affected cattle showed 100% cattle (skin nodule of various sizes), 55.55% (lymph node enlargement), 75% (high fever), 13.88% (brisket oedema), 19.44% (limb oedema), 8.33% (ventral abdomen oedema), 5.55% (facial oedema), 19.44% (lameness), 22.22% (respiratory distress), 2.77% (corneal opacity) and 27.78% (salivation and nasal discharge) as clinical signs. Almost all affected cattle showed multiple lesion at the same time, particularly in the last two disease periods. Comparatively, the nodular lesion is much more higher in the limb (33.1%), followed by the head and neck region (23.24%), and then other parts of the body. Haematological analysis reveals a significant decrease in red blood cell (RBC), haemoglobin (Hb), packed cell volume (PCV), mean corpuscular Hb concentration (MCHC), TLC and thrombocytes. During the illness and decline periods, mean corpuscular volume (MCV) increased, which is an indication of macrocytic hypochromic anaemia, lymphocytopenia and thrombocytopenia, and indicative of fluid therapy such as blood transfusion. The age group under 1 year is more vulnerable to LSD fatality, as lower levels of TLC, lymphocyte, and monocyte were found, indicating severe immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is concluded that disease stage\u2010wise and age\u2010wise clinico\u2010haematological studies have provided baseline data of LSD pathogenesis, which is essential to formulate an effective pharmacotherapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70549","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:50:16Z","timestamp":1754920216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Clinico\u2010Haematological Alterations of Lumpy Skin Disease Affected Cattle at Different Ages and Periods of Disease in Bangladesh"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-1782","authenticated-orcid":false,"given":"Md. Saiful Islam","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Anatomy &amp; Histology Faculty of Veterinary Animal and Biomedical Sciences Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6834-9206","authenticated-orcid":false,"given":"Md. Ashiqur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Intern veterinarian Faculty of Veterinary Animal and Biomedical Sciences Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiful","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Histology Faculty of Veterinary Animal and Biomedical Sciences Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Papri Rani","family":"Dey","sequence":"additional","affiliation":[{"name":"Intern veterinarian Faculty of Veterinary Animal and Biomedical Sciences Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Khademul","family":"Islam","sequence":"additional","affiliation":[{"name":"MS Fellow Department of Epidemiology &amp; Public Health Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8548-0267","authenticated-orcid":false,"given":"Sultana","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Jhenaidah Govt. Veterinary College  Jhenaidah Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-9303","authenticated-orcid":false,"given":"Md. Masudur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Animal and Biomedical Sciences Sylhet Agricultural University  Sylhet Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.5038"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09712119.1992.9705904"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119500537"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7482\/0003\u20109438\u201057\u2010018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638711425572"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198609000-00003"},{"key":"e_1_2_11_8_1","volume-title":"Infectious Diseases of Livestock With Special Reference to Southern Africa","author":"Coetzer J. 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