{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:45:19Z","timestamp":1773168319370,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The invasive nature of liver biopsy and the risk of complications make patients reluctant to undergo the procedure. This situation has necessitated the search for easily accessible haematological indexes such as neutrophil\u2010to\u2010lymphocyte ratio (NLR) and red cell distribution width to lymphocyte ratio (RDW\/LYM) to contribute to the clinical diagnosis and prognosis evaluation processes in dogs with cholangitis\u2010cholangiohepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study is to evaluate some predictive markers to contribute the clinical diagnosis in dogs with cholangitis\u2010cholangiohepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Medhods<\/jats:title>\n                    <jats:p>Seventeen client\u2010owned dogs with cholangitis\u2010cholangiohepatitis were randomly allocated. Nine clinically healthy dogs (control group) confirmed with clinical examination, complete blood count (CBC) and serum profiles were used. Cholangitis\u2010cholangiohepatitis was diagnosed in dogs with dilated bile ducts, thickened gallbladder wall up to 4\u00a0mm and increased parenchymal echogenicity. Clinical procedures including clinical examination, blood analyses and diagnostic abdominal ultrasonography were performed in all dogs. CBC indices such as NLR, mean platelet volume to platelet ratio (MPV\/PLT), red cell distribution width to platelet ratio (RDW\/PLT), monocyte\u2010to\u2010lymphocyte ratio (MLR), platelet\u2010to\u2010lymphocyte ratio (PLR) and RDW\/LYM were calculated using absolute CBC values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A final total of 10 dogs were enrolled in the study. NLR and RDW\/LYM ratios were significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 00.5) in dogs with cholangitis\u2010cholangiohepatitis compared to healthy ones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study suggest that the use of NLR and RDW\/LYM ratio in dogs with cholangitis\u2010cholangiohepatitis complex appears potentially promising. Larger prospective, case\u2010control studies are needed to further evaluate these findings. Veterinary practitioners can obtain valuable diagnostic data before possible invasive liver procedures by evaluating NLR and RDW\/LYM ratios, which are easily obtained from CBC parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70559","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:33:28Z","timestamp":1754750008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Some Predictive Indexes Are Potentially Promising Clinical Parameters in Dogs with Primary Cholangitis\u2010Cholangiohepatitis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-035X","authenticated-orcid":false,"given":"Ekrem \u00c7a\u011fatay","family":"\u00c7olako\u011flu","sequence":"first","affiliation":[{"name":"Small Animal Veterinary Teaching Hospital Department of Internal Medicine Faculty of Veterinary Medicine Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Small Animal Veterinary Teaching Hospital Department of Internal Medicine Faculty of Veterinary Medicine Aksaray University  Aksaray Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Sevim","sequence":"additional","affiliation":[{"name":"Small Animal Veterinary Teaching Hospital Department of Internal Medicine Faculty of Veterinary Medicine Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Evren","family":"Haydardedeo\u011flu","sequence":"additional","affiliation":[{"name":"Small Animal Veterinary Teaching Hospital Department of Internal Medicine Faculty of Veterinary Medicine Aksaray University  Aksaray Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ufuk","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Veterinary Medicine, Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043487"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S383558"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1632283"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2015.0070"},{"key":"e_1_2_10_6_1","first-page":"616","volume-title":"Infectious Diseases of the Dog and Cat","author":"Center S. 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