{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:17:10Z","timestamp":1772821030165,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["RS\u20102023\u201000232301"],"award-info":[{"award-number":["RS\u20102023\u201000232301"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cryptococcosis is the most common systemic fungal infection in cats, typically presenting with respiratory or neurological signs. However, cases without these hallmark symptoms are rare and often misdiagnosed. This case is noteworthy for its atypical presentation, where a cat developed systemic cryptococcosis without the typical respiratory or neurological involvement, making it particularly challenging to diagnose. In addition, the overlap of clinical signs with other diseases like lymphoma underscores the importance of considering cryptococcosis in differential diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 7\u2010year\u2010old castrated male Persian cat was referred due to generalized cutaneous nodules, including a prominent 4\u20135\u00a0cm nodule on the neck, and generalized lymphadenopathy. Neurological examination revealed an absent menace response in the left eye, raising suspicion of vision loss. Blood tests indicated hyperglobulinemia and the presence of medium\u2010to\u2010large lymphoid cells in the peripheral blood. Diagnostic imaging showed systemic lymphadenopathy, retinal detachment and minimal ascites. Fine needle aspiration of the lymph nodes revealed yeast\u2010like organisms, and culture confirmed\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                      . Initially treated with itraconazole, the therapy was switched to fluconazole due to better CNS penetration. The lymph node enlargement improved within one week, but further follow\u2010up was limited due to owner constraints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case emphasizes the diagnostic challenges posed by atypical presentations of feline cryptococcosis, particularly in the absence of respiratory and neurological symptoms. It highlights the importance of considering systemic fungal infections in the differential diagnosis of lymphadenopathy. The overlap with diseases like lymphoma further underscores the need for comprehensive diagnostic workups, including cytology and culture, to ensure accurate diagnosis and effective treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70564","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T09:09:44Z","timestamp":1756804184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare Case of Systemic Cryptococcal Lymphadenopathy in a Persian Cat"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9529-1313","authenticated-orcid":false,"given":"Chang\u2010Hyeon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Chonnam Nation University  Gwangju South Korea"},{"name":"College of Veterinary Medicine and BK21 FOUR Program Chonnam National University  Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8759-7764","authenticated-orcid":false,"given":"Keon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Chonnam Nation University  Gwangju South Korea"},{"name":"College of Veterinary Medicine and BK21 FOUR Program Chonnam National University  Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2166-1217","authenticated-orcid":false,"given":"Chang\u2010Yun","family":"Je","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Chonnam Nation University  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7831-5905","authenticated-orcid":false,"given":"Kwang\u2010Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Zoonotic and Vector Borne Disease Research, National Institute of Health Korea Disease Control and Prevention Agency  Cheongju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong\u2010Bin","family":"Ro","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Chonnam Nation University  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Chonnam Nation University  Gwangju South Korea"},{"name":"College of Veterinary Medicine and BK21 FOUR Program Chonnam National University  Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15625354"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.162753"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.695"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00381\u201013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019760"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098\u2010612X(03)00003\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02681219780000981"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20100813.2004.tb12701.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20100813.2006.00026.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13489218"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379435"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/515120"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01650\u201017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.01.009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.3.357"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.3.357"},{"key":"e_1_2_11_18_1","volume-title":"Atlas of Canine and Feline Peripheral Blood Smears","author":"Valenciano A. 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