{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:03Z","timestamp":1772118963065,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Therapeutic management of ivermectin overdose in a Shih Tzu dog using intravenous administration of intravenous lipid emulsion (ILE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>A 3\u2010year\u2010old female Shih Tzu dog weighing 2.5\u00a0kg was presented to a veterinary clinic in Tehran with ataxia, tremors, incoordination, negative PLR and menace reflex, bradycardia and salivation. The patient was treated with a 10\u00a0mg ivermectin tablet with the brand name Medimect in the last 12 h. Following the diagnosis of ivermectin intoxication, treatment with ILE was initiated. ILE was administered as a bolus of 1.5\u00a0mL\/kg in 1 min, followed by a dose of 0.25\u00a0mL\/kg\/min for 30 min as a CRI. The neurological symptoms of the patient began to decrease 2.5 h after the ILE therapy. Twenty\u2010four hours later, the patient was resuscitated, and all symptoms were resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current paper reports the successful treatment of ivermectin toxicity with ILE therapy in Iran. The education of veterinarians regarding the beneficial and varied roles of ILE therapy in different clinical settings is warranted, particularly in terms of the potential for ILE therapy to reverse the toxicities of various lipophilic drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70586","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T04:55:12Z","timestamp":1756270512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intralipid emulsion therapy for ivermectin toxicity in a dog"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-0300","authenticated-orcid":false,"given":"Ehsan","family":"Khaksar","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Science G.C Islamic Azad University Garmsar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9164-8434","authenticated-orcid":false,"given":"Hamed","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-4123","authenticated-orcid":false,"given":"Mahdieh","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4412-8465","authenticated-orcid":false,"given":"Salar","family":"Zehforosh","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"BSAVA Small Animal Formulary. 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