{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:26:36Z","timestamp":1790310396578,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic gingivostomatitis has been associated with increases in \u03b11\u2010acid glycoprotein and serum haptoglobin (Hp) in cats. However, serum amyloid A (SAA) and Hp have not been previously evaluated in cats with uncomplicated gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare SAA and Hp between cats with gingivitis and healthy cats, and to investigate the correlation between these two proteins and the severity of gingivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cross\u2010sectional study. Adult, FIV\u2010 and FeLV\u2010seronegative cats were included. The cats were allocated into two age\u2010 and sex\u2010matched groups. The case group included cats with gingivitis, and the control group included clinically and clinicopathologically healthy cats. The severity of gingivitis was assessed by the Total Mouth Periodontal Score (TMPS)\u2010G index. Serum samples were used to measure SAA and Hp using a previously validated turbidimetric immunoassay and haemoglobin\u2010binding method, respectively. The R statistical language was used for the statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 22 cats were included, 11 in each study group. The median (range) age of cats was 5.0 (3.0\u201311.0) years. The median Hp concentration was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) in the case group (2.40 [0.72\u20134.44] g\/L) compared with the control group (1.06 [0.50\u20131.42] g\/L). A significant correlation was found between Hp and TMPS\u2010G (rho\u00a0=\u00a00.636,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.040). The SAA was below the detection limit (0.4\u00a0mg\/L) in all samples of the control group and in 10\/11 samples of the case group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Feline gingivitis is associated with increased Hp, suggesting the presence of an acute\u2010phase reaction. Haptoglobin appears to be correlated with the severity of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70606","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:09:10Z","timestamp":1757783350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Amyloid A and Haptoglobin as Markers in Cats with Gingivitis\u2014Preliminary Study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-9891","authenticated-orcid":false,"given":"Ioannis L.","family":"Oikonomidis","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy Physiology and Pathology Institute of Infection Veterinary and Ecological Sciences University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kavarnos","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic School of Veterinary Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serafeim","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic School of Veterinary Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Joaquin","family":"Ceron","sequence":"additional","affiliation":[{"name":"Interdisciplinar Laboratory of Clinical Analysis University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kouki","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic School of Veterinary Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina K.","family":"Adamama\u2010Moraitou","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic School of Veterinary Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nectarios","family":"Soubasis","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic School of Veterinary Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.203"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00019.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00397.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.141.12.299"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7036344"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.7.2542"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(03)00055-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985875012005-00601"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3373-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/089875640802500303"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00012-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/089875641303000103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39752-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1999.214.09.1336"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/089875641303000413"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02590-2"},{"key":"e_1_2_11_19_1","article-title":"Periodontal Disease in Cats Under Primary Veterinary Care in the UK: Frequency and Risk Factors","volume":"25","author":"O'Neill D. 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