{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:18:37Z","timestamp":1787163517288,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Feeding broilers aflatoxin\u2010contaminated feed can disrupt the bird's performance, immune system and organs such as the liver, kidneys and heart. One possible strategy to minimise the inevitable impact of aflatoxins could be the use of toxic binders in the feed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The present study aimed to investigate the effect of mycotoxin binder magnotox (MAG) in reducing the toxicity of aflatoxin B\n                      <jats:sub>1<\/jats:sub>\n                      (AFB\n                      <jats:sub>1<\/jats:sub>\n                      ) on performance, lymphoid organs, blood parameters, immune response and haematology parameters of broiler chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 240 1\u2010day\u2010old male broiler chicks of Ross 308 strain with an average 1\u2010day weight of 43.47\u00a0\u00b1\u00a00.28\u00a0g were used. This experiment was conducted as a 2\u00a0\u00d7\u00a02 factorial in a completely randomised design with four treatments and six replications. The experimental diets included two levels of AFB\n                      <jats:sub>1<\/jats:sub>\n                      (0 and 200\u00a0\u00b5g\/kg) and two levels of MAG (0 and 1\u00a0g\/kg).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The interaction effects of AFB\n                      <jats:sub>1<\/jats:sub>\n                      and MAG showed that adding 1\u00a0g\/kg MAG to the AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010containing diet improved BWG compared to the AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010containing diet without MAG at 1\u201324, 25\u201342 and 1\u201342 days of age. Exposure to 200\u00a0\u00b5g\/kg AFB\n                      <jats:sub>1<\/jats:sub>\n                      increased the percentage of liver, kidney and pancreas, and the use of 1\u00a0g\/kg MAG in the AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010containing diet significantly reduced the weight of these organs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Regarding liver enzymes, MAG compensated for the increase in ALP, AST and ALT concentrations caused by AFB\n                      <jats:sub>1<\/jats:sub>\n                      and reduced them similarly to the control treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). AFB\n                      <jats:sub>1<\/jats:sub>\n                      exposure decreased IgG (24 and 42 days), IgM (24 days) and IgA (42 days) but the use of 1\u00a0g\/kg MAG in AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010contaminated diets was able to compensate for the negative effects of AFB\n                      <jats:sub>1<\/jats:sub>\n                      and significantly increase the concentration of IgG, IgM and IgA. The interaction of MAG and AFB\n                      <jats:sub>1<\/jats:sub>\n                      showed that IBD and ND titres were reduced in AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010contaminated diets at 24 and 42 days of age but the use of MAG increased IBD and ND titres (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Overall, broilers fed diets contaminated with 200\u00a0\u00b5g\/kg AFB\n                      <jats:sub>1<\/jats:sub>\n                      showed poor growth performance throughout the period due to impaired immune function and inflammation of immune organs, but supplementation with 1\u00a0g\/kg MAG counteracted the negative effects caused by AFB\n                      <jats:sub>1<\/jats:sub>\n                      and improved growth performance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70625","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:12:35Z","timestamp":1761289955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Clay\u2010 and Yeast\u2010Based Mycotoxin Binder on Performance, Lymphoid Organs, Blood Parameters, Immune Response and Haematology Parameters of Broilers Exposed to Aflatoxin B\n                    <sub>1<\/sub>"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2213-4594","authenticated-orcid":false,"given":"Payman Mahmoudi","family":"Nasr","sequence":"first","affiliation":[{"name":"Department of Animal Science, QaS.C. 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