{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:07:42Z","timestamp":1774271262089,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 4\u2010year\u2010old female neutered crossbreed dog was presented for a 2\u2010month history of intermittent vestibulo\u2010cerebellar ataxia and right head tilt. On admission, she presented clinical signs compatible with right paradoxical vestibular syndrome. Haematology showed moderate lymphocytosis, thrombocytopenia and hyperproteinaemia with hyperglobulinemia. Magnetic resonance imaging of the brain showed multiple, bilateral, ill\u2010defined lesions involving the white matter of the brainstem, cerebellum and forebrain with strong diffuse meningeal contrast enhancement. Cerebrospinal fluid cytology showed lymphocytic pleocytosis, and\n                    <jats:italic>Ehrlichia<\/jats:italic>\n                    spp. serology was positive. Treatment with doxycycline showed clinical improvement within 24 h, treatment was continued for 6 weeks. A follow\u2010up magnetic resonance imaging study was performed after treatment and showed complete resolution of the previous lesions. Cerebrospinal fluid analysis showed only albumin\u2010cytological dissociation. Since treatment initiation, the patient remained asymptomatic. Three months after hospital discharge, no further episodes were reported.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70661","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:20:39Z","timestamp":1762201239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central Nervous System Vasculitis Due to\n                    <i>Ehrlichia canis<\/i>\n                    in a Dog"],"prefix":"10.1002","volume":"11","author":[{"given":"Miguel Benito","family":"Benito","sequence":"first","affiliation":[{"name":"Hamilton Specialist Referrals Part of IVC Evidensia, High Wycombe  Buckinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Anicura Ars Veterinaria  Barcelona Catalunya Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Romero\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hamilton Specialist Referrals Part of IVC Evidensia, High Wycombe  Buckinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2012.05.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12582"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.08.028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0401"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0466.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcam.2022.100735"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.07.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.50"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.1102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00915-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5326\/0390379"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13788"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/379627"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.01.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/acve-2017-0025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04363-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0649-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60069-5"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"84","article-title":"Granular Lymphocytosis and Hyperproteinemia in Dogs With Chronic Ehrlichiosis","volume":"27","author":"Weiser M. G.","year":"1991","journal-title":"Journal of the American Animal Hospital Association"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70661","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:15:21Z","timestamp":1774268121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/vms3.70661"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70661","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2024-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70661"}}