{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:58:43Z","timestamp":1774270723362,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This case report documents the successful treatment of a cat with proliferative necrotizing otitis externa (PNOE) using oclacitinib. Novel to this report, two episodes of delayed relapses occurred prior to complete spontaneous resolution, with an apparent dose\u2010dependent response to oclacitinib. Oclacitinib led to complete remission of the initial lesions and those of the first relapse, and the lesions of the second relapse resolved spontaneously. This adds additional evidence to support the use of oclacitinib as an alternative or adjunctive off\u2010label treatment for PNOE, especially in refractory cases. Further studies are needed to assess the safety of long\u2010term use, and to confirm ideal dose rates and treatment duration.<\/jats:p>","DOI":"10.1002\/vms3.70696","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T18:28:58Z","timestamp":1762885738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proliferative Necrotising Otitis Externa in a Cat Treated Successfully With Oclacitinib Maleate With Two Delayed Relapses"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4334-0047","authenticated-orcid":false,"given":"Tian","family":"Chee","sequence":"first","affiliation":[{"name":"Animal Skin and Ear Specialists Melbourne Veterinary Specialist Centre  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Robson","sequence":"additional","affiliation":[{"name":"Animal Skin and Ear Specialists Melbourne Veterinary Specialist Centre  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12949"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13269"},{"key":"e_1_2_10_4_1","unstructured":"FDA Freedom of Information. 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Vlaams Diergeneeskundig Tijdschrift.Ghent University.https:\/\/doi.org\/10.21825\/vdt.85859.","DOI":"10.21825\/vdt.85859"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2010.00999.x"},{"key":"e_1_2_10_14_1","unstructured":"Walczak M. andG.Burton.2020. \u201cOclacitinib\u2014Can It Do More Than Treat Atopic Dermatitis?\u201d9th World Congress of Veterinary Dermatology Continuing Education Proceedings174\u2013180.https:\/\/articlereview.pubmate.in\/#\/?templateID=bd788db865c24abab5368320c20859c7103306982."}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:12:11Z","timestamp":1774267931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/vms3.70696"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70696","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.70696\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v5\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v4\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70696\/v4\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70696"}}