{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:52:19Z","timestamp":1787863939502,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bioactive peptides present antimicrobial, antioxidative and immunomodulatory activities with beneficial effects on broiler chickens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This experiment was conducted to examine the influence of dietary supplemental cottonseed bioactive peptides (CBP) on growth performance, oocysts per gram of faeces (OPG), intestinal morphology, immune responses and interleukin\u20106 (IL\u20106) gene expression in broilers exposed to coccidial infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 420 broiler chicks (Ross 308) were assigned to seven dietary treatments in a completely randomized design during 10\u201345\u00a0days of age. Experimental treatments included: (1) CON+, broiler chickens without challenge; (2) CON\u2013, birds challenged with coccidiosis; (3\u20135) the CON\u2013 birds fed diets containing 4\u00a0g\/kg, 5\u00a0g\/kg or 6\u00a0g\/kg CBP, respectively; (6) the CON\u2013 birds fed diets containing 0.2\u00a0g\/kg diclazuril; (7) the CON\u2013 birds fed diets containing 0.5\u00a0g\/kg salinomycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infection alleviated daily feed intake and growth of broilers fed a basal diet during 31\u201338 days of age (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00\u00b705), which ameliorated after supplementation of 6\u00a0g\/kg CBP (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Dietary 4 or 6\u00a0g\/kg CBP, diclazuril or salinomycin compensated for the impairment in the feed conversion ratio of\n                      <jats:italic>Eimeria<\/jats:italic>\n                      spp. challenged broilers during 31\u201345 days of age (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Coccidiosis challenge increased OPG; however, the OPG value decreased when the diet contained CBP or anti\u2010coccidiosis drugs (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Antibody titer against sheep red blood cells improved in challenged birds fed 6\u00a0g\/kg CBP (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dietary CBP decreased the negative effects of coccidiosis, whereby supplemented birds had similar immune responses or even better growth performance than birds receiving anticoccidials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70700","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:32:16Z","timestamp":1763134336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Dietary Cottonseed Bioactive Peptides Compared to Diclazuril or Salinomycin on Reducing Adverse Effects of Coccidiosis Challenge in Broiler Chickens"],"prefix":"10.1002","volume":"11","author":[{"given":"Mohammad Reza","family":"Yazdani","sequence":"first","affiliation":[{"name":"Department of Animal Sciences ShK.C. Islamic Azad University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5517-4524","authenticated-orcid":false,"given":"Farshid","family":"Kheiri","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences ShK.C. Islamic Azad University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Faghani","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences ShK.C. Islamic Azad University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sharifzadeh","sequence":"additional","affiliation":[{"name":"Department of Veterinary ShK.C. Islamic Azad University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2014-04212"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/JAN.2018.1"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"147","article-title":"Effect of Vegetable Oil Source and l\u2010Carnitine Supplements on Growth Performance, Carcass Characteristics and Blood Biochemical Parameters of Japanese Quails (Coturnix japonica)","volume":"7","author":"Abedpour A.","year":"2017","journal-title":"Iranian Journal of Applied Animal Science"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/79.4.489"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pev022"},{"key":"e_1_2_11_7_1","volume-title":"Official Methods of Analysis","author":"AOAC","year":"1965"},{"key":"e_1_2_11_8_1","volume-title":"Official Methods of Analysis","author":"AOAC","year":"2006"},{"key":"e_1_2_11_9_1","volume-title":"Ross 308 Broiler: Nutrition Specification","author":"Aviagen","year":"2014"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2008-00330"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"51","article-title":"Comparison of the Effect of Probiotic, Prebiotic, Salinomycin and Vaccine in Control of Coccidiosis in Broiler Chickens","volume":"20","author":"Behnamifar A.","year":"2019","journal-title":"Iranian Journal of Veterinary Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-020-00837-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/animres:2004006"},{"key":"e_1_2_11_14_1","unstructured":"De Gussem M.2007. \u201cCoccidiosis in Poultry: Review on Diagnosis Control Prevention and Interaction With Overall Gut Health.\u201d InProceedings of the 16th European Symposium on Poultry Nutrition 253\u2013261.World's Poultry Science Association."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2005.00727.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14691"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.009065"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2007.01.013"},{"issue":"1","key":"e_1_2_11_19_1","first-page":"89","article-title":"The Potential of Antioxidant Rich Essential Oils Against avian Coccidiosis","volume":"73","author":"Idris M.","year":"2017","journal-title":"oultry Science Journal"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-8401(00)00223-6"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(70)90063-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.09.048"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"27","article-title":"Effects of Canola Bioactive Peptides on Performance, Digestive Enzyme Activities, Nutrient Digestibility, Intestinal Morphology and Gut Microflora in Broiler Chickens","volume":"4","author":"Karimzadeh S.","year":"2016","journal-title":"Polultry Science Journal"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(01)00410-X"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2016.11.002"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2020.1844085"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13781"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11182738"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2013.09.013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijps.2006.868.872"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-021-02934-6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-8401(03)00163-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2005.07.014"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1071\/AN12209"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-025-10448-y"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3906\/vet-1410-65"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pez346"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2010-00753"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1982.43.03.507"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/1262\/6\/062035"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.01.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00479-4"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2010.506908"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2008-00533"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540105.2017.1311308"},{"issue":"3","key":"e_1_2_11_48_1","first-page":"423","article-title":"Antimicrobial Peptides in Housefly Larvae (Musca domestica) Affect Intestinal Lactobacillus acidophilus and Mucosal Epithelial Cells in Salmonella pullorum\u2010Infected Chickens","volume":"23","author":"Wang Z.","year":"2017","journal-title":"Kafkas \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511007240"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/b310574a"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0592412"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1869-x"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:15:46Z","timestamp":1774268146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/vms3.70700"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70700","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70700"}}