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Clinical signs were compatible with a space\u2010occupying cerebral lesion, and magnetic resonance imaging revealed a multilobular mass with extracranial and intracranial components, which asserted marked forebrain mass effect and apparently originated from the frontal and parietal bones. Due to clinical deterioration and poor prognosis, the cat was euthanized and a post\u2010mortem examination performed. Gross lesions confirmed a solitary neoplasm, firmly attached to the dura mater, overlying and compressing the left cerebral hemisphere. The neoplasm was not adherent to bony structures of the skull, but local osteolytic destruction of the frontal bone and cribriform plate allowed its extension outside the calvarium and into the nasal sinuses. The tissue was diagnosed by histological assessment as an osteosarcoma. Primary extraskeletal osteosarcomas of the meninges are exceedingly rare in all species, and to the authors\u2019 knowledge, have never been reported in cats. As the clinical behaviour is very different from more typically encountered neoplasms, this possibility, although rare, may be considered as a differential diagnosis for feline intracranial tumours.<\/jats:p>","DOI":"10.1002\/vms3.70771","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:11:17Z","timestamp":1770880277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Meningeal Extraskeletal Osteosarcoma in a Domestic Shorthaired Cat: Case Report and Review of Comparative Pathology"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-9215","authenticated-orcid":false,"given":"Jacqueline","family":"Poldy","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies Veterinary Pathology Unit the University of Edinburgh, Easter Bush Campus  Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-0246","authenticated-orcid":false,"given":"Dario","family":"Costanza","sequence":"additional","affiliation":[{"name":"Interdepartmental Centre of Veterinary Radiology University of Napoli \u201cFederico II\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aran","family":"Nagendran","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies Hospital for Small Animals the University of Edinburgh, Easter Bush Campus  Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8537-5704","authenticated-orcid":false,"given":"Albert","family":"Aguilera\u2010Padros","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies Hospital for Small Animals the University of Edinburgh, Easter Bush Campus  Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Liuti","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies Hospital for Small Animals the University of Edinburgh, Easter Bush Campus  Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Del\u2010Pozo","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies Veterinary Pathology Unit the University of Edinburgh, Easter Bush Campus  Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200008000-00036"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200108000-00025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005756930169"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X231199731"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2018-000770"},{"key":"e_1_2_11_7_1","first-page":"737","article-title":"Primary Intracerebellar Osteosarcoma Arising Within an Epidermoid Cyst","volume":"122","author":"Cannon T. 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