{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:00:45Z","timestamp":1785085245852,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Arian broiler, an important native Iranian breed, shows heightened sensitivity to metabolic disturbances caused by lipopolysaccharide (LPS). This study evaluated whether glycyrrhizin could mitigate LPS\u2010associated physiological disruptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a controlled trial, 100 Arian broilers (21\u2010day\u2010old, mean weight 750\u00a0g) were randomly allocated into five experimental groups: (1) ICV glycyrrhizin dose\u2010response assessment (1, 2 and 4 \u00b5g) evaluating feeding behaviour; (2) ICV LPS challenge (12.5, 25 and 50\u00a0ng) with 8\u2010h monitoring of feed intake and cloacal temperature; (3) IP glycyrrhizin administration (12.5, 25 and 50\u00a0mg\/kg) to assess effects on feed consumption; (4) IP glycyrrhizin + ICV LPS interaction study; and (5) ICV glycyrrhizin + LPS co\u2010administration group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LPS administration induced characteristic biphasic temperature dysregulation, with significant hypothermia at 3\u00a0h (\u22121.3 \u00b1 0.4\u00b0C vs. controls) followed by hyperthermia at 8\u00a0h (+1.1 \u00b1 0.3\u00b0C), accompanied by feed intake reduction (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). The findings indicated that feed intake increased significantly following the injection via both intraperitoneal and intracerebroventricular of glycyrrhizin in a dose\u2010dependent manner (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), but IP delivery (25 and 50\u00a0mg\/kg) showed comparable effects with 20\u201330\u00a0min delayed onset. Co\u2010administration completely prevented LPS\u2010induced disturbances at optimal doses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Glycyrrhizin counteracts LPS\u2010induced thermoregulatory and feeding disturbances in Arian broilers through rapid\u2010acting mechanisms. While the physiological improvements align with anti\u2010inflammatory responses observed in other species, direct molecular evidence remains to be established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70777","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:35:14Z","timestamp":1768293314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycyrrhizin's Potential to Modulate Feeding Behaviour by Neutralizing Reduced Feed Intake in Inflamed Arian Broilers"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-4618","authenticated-orcid":false,"given":"Mitra","family":"Nowrouzpour","sequence":"first","affiliation":[{"name":"Department of Basic Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2278","authenticated-orcid":false,"given":"Amin","family":"Rahdari","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-3826","authenticated-orcid":false,"given":"Farshid","family":"Hamidi","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","volume-title":"Metabolic Syndrome: A Comprehensive Textbook","author":"Affinati A. 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