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Morphological characteristics of the mass during necropsy were consistent with a mediastinal abscess in the left hemithorax. Histological examination identified a disseminated histiocytic sarcoma involving spleen, kidneys, multiple lymph nodes, diaphragm and parietal pleura, as well as a concurrent follicular lymphoma in a separate lymph node. A mixed metastatic infiltrate composed of both neoplasms was found within the capsule of the intrathoracic abscess. Immunohistochemical analysis (Iba\u20101, CD3, PAX\u20105, IRF\u20104, pancytokeratin AE1\/AE3 and Ki\u201067) confirmed both neoplasms and revealed mild IRF\u20104 immunoreactivity for histiocytic sarcoma cells. The histomorphologic and immunohistochemical features of the histiocytic sarcoma in this\n                    <jats:italic>Lemur catta<\/jats:italic>\n                    were characteristic of this condition in other species. This report documents the first case of histiocytic sarcoma in\n                    <jats:italic>Lemur catta<\/jats:italic>\n                    , providing novel histopathological and immunohistochemical insights of this condition in prosimians.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70800","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:32:42Z","timestamp":1769783562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histological and Immunohistochemical Characterization of a Histiocytic Sarcoma Associated With a Follicular Lymphoma in a Ring\u2010tailed Lemur (\n                    <i>Lemur catta<\/i>\n                    )"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6149-0591","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Aradilla","sequence":"first","affiliation":[{"name":"VISAVET Health Surveillance Centre, Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Canales","sequence":"additional","affiliation":[{"name":"Mundomar Veterinary Services  Benidorm Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3830-216X","authenticated-orcid":false,"given":"Teresa","family":"Lorenzo\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health Sciences, CEU Cardenal Herrera University, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Mainez","sequence":"additional","affiliation":[{"name":"La Marina Exotics Veterinary Center  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Aguil\u00f3\u2010Gisbert","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Hospital, CEU Cardenal Herrera University, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Marbella","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Hospital, CEU Cardenal Herrera University, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1299-2592","authenticated-orcid":false,"given":"Javier Mar\u00eda De","family":"Pablo\u2010Moreno","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre, Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9543-313X","authenticated-orcid":false,"given":"Antonio","family":"Rodr\u00edguez\u2010Bertos","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre, Complutense University of Madrid  Madrid Spain"},{"name":"Department of Internal Medicine and Animal Surgery Faculty of Veterinary Medicine, Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2022.12.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20102141.2001.02841.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00655"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1638\/2017\u20100242.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"Clark.2020.Lemurs. 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