{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:22Z","timestamp":1791798562436,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluated the relationship between intraocular pressure (IOP) and carbonic anhydrase (CA) activity in healthy pregnant and non\u2010pregnant Brown Swiss cows. Fourteen cows (seven pregnant, seven non\u2010pregnant; average age 4.5\u00a0\u00b1\u00a00.3 years; body weight 500\u00a0\u00b1\u00a050 kg) were included. After clinical and ophthalmologic examinations, IOP was measured in both eyes using a rebound tonometer on 10 consecutive mornings (9\u201312 AM). Blood samples were collected for the determination of plasma CA activity. Data were analysed with parametric and non\u2010parametric tests, and right\u2010left eye agreement was assessed via Bland\u2010Altman analysis. Pregnant cows showed significantly lower mean IOP (22.19\u00a0\u00b1\u00a01.43\u00a0mmHg) than non\u2010pregnant cows (24.50\u00a0\u00b1\u00a01.60\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), with no significant difference between the eye sides. Plasma CA activity did not differ between groups, but IOP changes correlated positively with CA level changes in pregnant (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.31;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and non\u2010pregnant cows (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.38;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001). Pregnancy significantly reduces IOP in cattle, and CA activity is associated with IOP changes, suggesting that hormonal and hemodynamic alterations during pregnancy may influence intraocular fluid dynamics. The similarity between eyes facilitates clinical evaluation. The findings may inform further studies on the role of CA in ocular physiology during pregnancy.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70833","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:49:44Z","timestamp":1771588184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Intraocular Pressure and Carbonic Anhydrase Enzyme Activity in Cattle: Implications for Veterinary Ophthalmology"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-9012","authenticated-orcid":false,"given":"Selvinaz","family":"Yakan","sequence":"first","affiliation":[{"name":"Animal Health Department Ele\u015fkirt Celal Oru\u00e7 School of Animal Production A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8316","authenticated-orcid":false,"given":"Cafer Tayer","family":"\u0130\u015fler","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Surgery Mustafa Kemal \u00dcniversity  Hatay T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-9334","authenticated-orcid":false,"given":"Mucip","family":"Geni\u015fel","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Botany A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-7500","authenticated-orcid":false,"given":"Kader","family":"Yolcu","sequence":"additional","affiliation":[{"name":"Animal Health Department Ele\u015fkirt Celal Oru\u00e7 School of Animal Production A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-3196","authenticated-orcid":false,"given":"Ahmet","family":"Bayat","sequence":"additional","affiliation":[{"name":"Department of Agricultural Business Ele\u015fkirt Celal Oru\u00e7 School of Animal Production, A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lyas","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Animal Science Institute of Graduate Programs A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1233s"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2011.12.2.171"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11081329"},{"key":"e_1_2_12_5_1","volume-title":"Arthur's Veterinary Reproduction and Obstetrics","author":"Arthur G. 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T.\u0130\u015fler M.Geni\u015fel K.Yolcu andA.Bayat.2024.Evaluation of the Relationship Between Intraocular Pressure and Carbonic Anhydrase Activity in Pregnant and Non\u2010Pregnant Cows.\u2018\u2019 paper presented at 18th National and 4th International Veterinary Surgery Congress Antalya T\u00fcrkiye October 27\u201330."},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.824925"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090180099043"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:27:10Z","timestamp":1791797230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/vms3.70833"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70833","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70833"}}