{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:25Z","timestamp":1791798565960,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a rare case of a spontaneous composite tumour with the histopathological characteristics of B\u2010cell lymphoblastic lymphoma and histiocytic sarcoma in a 104\u2010week\u2010old male C57BL\/6 mouse. It appeared to be a large, well\u2010circumscribed intra\u2010abdominal mass, presumably originating from a mesenteric lymph node. Histological examination revealed two distinct neoplastic cell populations, including small\u2010 to intermediate\u2010sized CD20\u2010 and Pax5\u2010positive lymphoid cells and large pleomorphic histiocytes expressing Iba1. Both cell types were strongly stained by proliferating cell nuclear antigen, which is indicative of high proliferative activity. No evidence of metastases was observed in other organs. While single cases of similar composite neoplasms have been reported in humans, this is the first documented case in a laboratory mouse. These findings expand the known spectrum of spontaneous hematopoietic tumours in aged mice and highlight the importance of comprehensive histopathological and immunophenotypic evaluation in diagnosing atypical lesions.<\/jats:p>","DOI":"10.1002\/vms3.70837","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T17:29:22Z","timestamp":1771176562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Development of B\u2010Cell Lymphoblastic Lymphoma and Histiocytic Sarcoma in a C57BL\/6 Laboratory Mouse: A Case Report"],"prefix":"10.1002","volume":"12","author":[{"given":"Yujeong","family":"Lee","sequence":"first","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkyoung","family":"Sung","sequence":"additional","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Eun","family":"Sung","sequence":"additional","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Ku","family":"Kang","sequence":"additional","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Gyeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-2690","authenticated-orcid":false,"given":"Il\u2010Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-687X","authenticated-orcid":false,"given":"Sijoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Preclinical Research Center Daegu\u2010Gyeongbuk Medical Innovation Foundation  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-4-384"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03045.x"},{"key":"e_1_2_9_4_1","article-title":"Primary Duodenal T\/Histiocyte\u2010Rich Large B\u2010Cell Lymphoma Complicated With Obstructive Jaundice: A Case Report and Review of Literature","volume":"17","author":"Chen X.\u2010Y.","year":"2025","journal-title":"World Journal of Gastrointestinal Surgery"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623319867053"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0773-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02783-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.3.719"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(99)80006-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810363705"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231166658"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.12.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339602400606"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"Nakamura K. K.Kuramoto K.Shibasaki S.Shumiya andK.Ohtsubo.1992. \u201cAge\u2010Related Incidence of Spontaneous Tumors in SPF C57BL\/6 and BDF1 Mice.\u201dJikken Dobutsu. 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