{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:54:18Z","timestamp":1791204858520,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To evaluate the effects of prenatal ursodeoxycholic acid (UDCA) and probiotics\u2014alone or combined\u2014on colostrum quality and lamb survival in ewes. Forty Middle Anatolian Merino ewes were randomized to control, UDCA (5\u00a0mg\/kg\/day), PRO (probiotic 0.2\u00a0mL\/kg; 6.2\u00a0\u00d7\u00a010\n                    <jats:sup>7<\/jats:sup>\n                    \u00a0colony\u2010forming unit (CFU)\/mL\u00a0\u2248\u00a01.24\u00a0\u00d7\u00a010\n                    <jats:sup>7<\/jats:sup>\n                    \u00a0CFU\/kg) or UDCA\u00a0+\u00a0PRO for the last month of gestation. Maternal blood\/colostrum was sampled pre\u2010 and postpartum; lamb serum was sampled at 24\u00a0h to assess immunoglobulin G (IgG), total antioxidant capacity (TAC), total oxidant status (TOS) and colostrum composition (IgG, fat, protein and lactose). Growth and survival were monitored to weaning. Maternal treatments significantly affected colostral IgG (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.017; highest in UDCA\u00a0+\u00a0PRO). In lambs, IgG (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.037), total protein (TP) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.021) and albumin (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.011) differed by group, favouring UDCA\u00a0+\u00a0PRO. Survival improved with treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0014). Across groups, time effects were observed for triglycerides (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002), gamma\u2010glutamyl transferase (GGT) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and bilirubin (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004). Treatment\u2010specific changes included PRO increasing colostrum fat (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.010) and lactose (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.050) and lowering maternal GGT (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.021) while elevating TOS (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.032) and TAC (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.039); UDCA\u00a0+\u00a0PRO increased postpartum TOS (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.034) and TAC (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.005); UDCA altered glucose and triglycerides (both\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015). In hierarchical regression, maternal IgG and colostrum IgG positively predicted neonatal IgG (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.005). A higher order interaction suggested attenuation of transfer efficiency when maternal IgG, maternal TP and colostrum IgG were simultaneously high (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.088). Combined UDCA\u00a0+\u00a0PRO most consistently enhanced passive immunity indicators and survival.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70859","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:09:47Z","timestamp":1785341387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Prenatal Ursodeoxycholic Acid and Probiotic Supplementation on Stress Parameters, Immune Response and Lamb Survival Rates in Ewes"],"prefix":"10.1002","volume":"12","author":[{"given":"M. Burak","family":"Ates","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pathology Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Aladag","sequence":"additional","affiliation":[{"name":"Bahri Dagdas International Agricultural Research Institute  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-7821","authenticated-orcid":false,"given":"Durmus","family":"Hatipoglu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Physiology Selcuk University  Konya 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