{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:20Z","timestamp":1791798560842,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the neuroprotective effects of sweet potato petioles and leaves (PL), which are rich in polyphenols with antioxidant and anti\u2010inflammatory properties, using a gerbil model of transient cerebral ischaemia. We also evaluated the preventive potential of continuous PL intake against ischaemic brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Custom diets, formulated by adding 1% or 10% PL powder to MF standard diet, were provided ad libitum to gerbils after a 5\u2010min bilateral common carotid artery occlusion for 7 days (post\u2010ischaemia PL providing group). Diets were also provided from 7 days before to 7 days after the ischaemic episode (pre\u2010ischaemia PL providing group, total 14 days). The number of viable neurons in the hippocampal CA1 region was assessed on postoperative Day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The number of viable neurons was significantly higher in both post\u2010 and pre\u201010% PL groups compared with that in the MF group (43.90\u00a0\u00b1\u00a03.28 in MF, 66.55\u00a0\u00b1\u00a06.60 in post 10% PL and 69.56\u00a0\u00b1\u00a03.30 in pre 10% PL;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), although no significant differences were observed in the post\u2010 and pre\u20101% PL groups (55.49\u00a0\u00b1\u00a03.19 in post 1% PL 47.27\u00a0\u00b1\u00a02.61 in pre 1% PL). Moreover, comparison between the pre\u2010 and post\u201010% PL groups indicated that pre\u2010ischaemic administration resulted in slightly higher number of viable neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous intake of sweet potato PL may support the prevention and mitigation of neuronal damage in ischaemic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70874","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:20:15Z","timestamp":1773015615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effect of Sweet Potato Petiole and Leaf Dry\u2010Powder in a Gerbil Model of Transient Cerebral Ischaemia"],"prefix":"10.1002","volume":"12","author":[{"given":"Kazuhisa","family":"Sugai","sequence":"first","affiliation":[{"name":"Institute for Integrated Sports Medicine Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Oda","sequence":"additional","affiliation":[{"name":"Division of Basic Science School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Applied Life Science Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Basic Science School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Division of Basic Science School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Applied Life Science Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Murakoshi","sequence":"additional","affiliation":[{"name":"Asahi Animal Hospital  Kokubunji\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kobayashi Regenerative Research Institute, LLC Wakayama\u2010shi, Wakayama Japan"},{"name":"TES Holdings Inc.  Taito\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanobu","family":"Hirano","sequence":"additional","affiliation":[{"name":"TES Holdings Inc.  Taito\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadahiko","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Kobayashi Regenerative Research Institute, LLC Wakayama\u2010shi, Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Basic Science School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"},{"name":"Kobayashi Regenerative Research Institute, LLC Wakayama\u2010shi, Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Hakamata","sequence":"additional","affiliation":[{"name":"Division of Basic Science School of Veterinary Nursing and Technology Nippon Veterinary and Life Science University  Musashino\u2010shi Tokyo Japan"},{"name":"Research Center for Animal Life Science Nippon Veterinary and Life Science University Musashino \u2010 shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.435"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061141"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-024-05897-z"},{"issue":"8","key":"e_1_2_12_8_1","first-page":"802","article-title":"Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters With a High\u2010Cholesterol Diet","volume":"11","author":"Chang H. H.","year":"2021","journal-title":"Life (Basel)"},{"key":"e_1_2_12_9_1","unstructured":"Chen W. P. T. J.Mao L.Fan et\u00a0al.2011.\u201c[Effect of Purple Sweet Potato on Lipid Metabolism and Oxidative Stress in Hyperlipidemic Rats].\u201d Zhejiang Da Xue Xue Bao. Yi Xue Ban =Journal of Zhejiang University. Medical Sciences40 no.4:360\u2013364."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010273"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11071058"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01997E"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt141"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507761792"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9101023"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2020.25.4.375"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279410"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1175907"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527318666191021144126"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2022.681.687"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01119-z"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb5916"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7021"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr215"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/acb394224"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00642-y"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14719"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90833-2"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.12239"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2279-5"},{"key":"e_1_2_12_31_1","article-title":"Ipomea batatas Leaf Powder From Cameroon: Antioxidant Activity and Antihyperlipidemic Effect in Rats Fed With a High\u2010Fat Diet","volume":"2021","author":"Mbouche Fanmoe M. J.","year":"2021","journal-title":"Journal of Lipid Research"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31784"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00032C"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15010003"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13111114"},{"key":"e_1_2_12_36_1","article-title":"Impact of Daily Administration of Blackberry Extract on Gerbil Model of Transient Cerebral Ischemia","volume":"39","author":"Oda A.","year":"2024","journal-title":"Acta Cirurgica Brasileira"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2023.8216"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjos-2020-100115"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-05137-3"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14264"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijpi.14.3.75"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01822.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11020401"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.11.005"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15110713"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14049"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718817477"},{"key":"e_1_2_12_48_1","volume-title":"AVMA Guidelines for the Euthanasia of Animals: 2020 Edition","author":"Underwood W.","year":"2020"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1744512"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05388-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125937"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40568-9"},{"key":"e_1_2_12_53_1","unstructured":"Zhang H. H. Y.Cao andZ.Zeng.2016.\u201c[Effect of Resveratrol Preconditioning on Myocardial Dysfunction After Cardiac Arrest in Rats].\u201d Sichuan Da Xue Xue Bao. Yi Xue Ban =Journal of Sichuan University. Medical Science Edition47 no.2:152\u2013158."},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02671B"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:26:27Z","timestamp":1791797187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/vms3.70874"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70874","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.70874\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70874\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70874\/v1\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70874"}}