{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:47:13Z","timestamp":1791906433496,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Proteus mirabilis<\/jats:italic>\n                      (\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      ) is an opportunistic zoonotic pathogen that can be mutually transmitted with humans (\n                      <jats:italic>Homo sapiens<\/jats:italic>\n                      ); knowledge on\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      infection in cynomolgus monkeys (\n                      <jats:italic>Macaca fascicularis<\/jats:italic>\n                      ) remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To isolate and characterize the diarrhoeal pathogen from a cynomolgus monkey; a bacterial strain MF103012 was isolated from the faeces of a diarrhoeal cynomolgus monkey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      was identified via morphology, biochemical profiling and 16S rRNA sequencing. Polymerase chain reaction (PCR) was used to detect key virulence genes. Antibiotic susceptibility was determined by Kirby\u2013Bauer disc diffusion using 24 antibiotics of\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      . Pathogenicity was assessed by intraperitoneal injection in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In our study, we successfully isolated and identified\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      from the faeces of diarrhoeal cynomolgus monkey. The isolated strain carried ureC, zapA, rsmA, hpmA, fliL, ucaA and atfA virulence genes. Strain MF103012 was susceptible to 19 antibiotics but resistant to vancomycin and erythromycin, and it induced morbidity and one case of mortality in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Endowed with the trait of cross\u2010species transmission,\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      has become an opportunistic pathogen that requires focused attention in both the prevention and control of zoonoses and clinical anti\u2010infective therapy. The results of this study improve our understanding of the isolated and identified\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      from the intestinal tract of diarrhoeal cynomolgus monkeys, and also lays groundwork for diagnosis and treatment of\n                      <jats:italic>P. mirabilis<\/jats:italic>\n                      in primate colonies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70921","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:00:17Z","timestamp":1775736017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation, Identification and Pathogenicity Analysis of\n                    <i>Proteus mirabilis<\/i>\n                    in Cynomolgus Monkey From Yunnan, China"],"prefix":"10.1002","volume":"12","author":[{"given":"Heling","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.926"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88861-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp-0009-2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00235-8"},{"key":"e_1_2_11_6_1","first-page":"352","article-title":"Comparison of Phenotypic and Virulence Genes Characteristics in Human and Chicken Isolates of Proteus mirabilis","volume":"10","author":"Barbour E. 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