{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:46:44Z","timestamp":1791906404065,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      is a Gram\u2010positive opportunistic pathogen commonly found in the gastrointestinal tract of humans and animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to describe a clinical case of multidrug\u2010resistant\n                      <jats:italic>E. faecium<\/jats:italic>\n                      ST80 respiratory tract infection that progressed to sepsis in a dog.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An 8\u2010year\u2010old, 20\u2010kg castrated male mixed\u2010breed dog presented with acute respiratory distress, haemoptysis and systemic inflammatory signs. The clinical condition deteriorated, progressing to acute respiratory distress syndrome and respiratory fatigue, which ultimately resulted in mortality. Diagnostic evaluation included cytological examination, bacterial and viral infection testing and histological analysis of tissue samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      isolates from the nasal swab, liver, kidney and rectum exhibited identical resistance profiles and resistance to all antibiotics tested except vancomycin, nitrofurantoin and chloramphenicol.\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      isolates from the liver, kidney and rectum were characterised using whole\u2010genome sequencing. The isolates carried multiple antibiotic resistance and virulence genes (\n                      <jats:italic>scm<\/jats:italic>\n                      ,\n                      <jats:italic>acm<\/jats:italic>\n                      ,\n                      <jats:italic>efaAfm<\/jats:italic>\n                      and\n                      <jats:italic>sgrA<\/jats:italic>\n                      ). Additionally, a high genetic similarity was observed among\n                      <jats:italic>E. faecium<\/jats:italic>\n                      isolates from the liver and kidney, supporting systemic dissemination of a single\n                      <jats:italic>E. faecium<\/jats:italic>\n                      clone consistent with sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings emphasise the clinical significance of enterococcal infections and their potential role in disease progression, underscoring the importance of managing virulent and drug\u2010resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      infections in dogs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70972","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:49:41Z","timestamp":1777535381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Sepsis Caused by ST80 Multidrug\u2010Resistant\n                    <i>Enterococcus faecium<\/i>\n                    With Concurrent\n                    <i>Klebsiella pneumoniae<\/i>\n                    Infection in a Dog"],"prefix":"10.1002","volume":"12","author":[{"given":"Hyung\u2010min","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Min","family":"La","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010ram","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-6574","authenticated-orcid":false,"given":"Dong\u2010Yeop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-1261","authenticated-orcid":false,"given":"Hyun\u2010Jung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"},{"name":"KU Center for Animal Blood Medical Science Konkuk University  Seoul Republic of Korea"},{"name":"KU I'M DOgNOR Blood Donation Center Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yeon","family":"Hyeon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Medicine Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.02.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1310.10088"},{"key":"e_1_2_11_5_1","volume-title":"VET01S \u2010 Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13359"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/coan.2015.20.10.565"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201046976\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.70228"},{"issue":"7","key":"e_1_2_11_10_1","first-page":"769","article-title":"Textbook of Veterinary Internal Medicine, 8th Edition","volume":"59","author":"Ettinger S. 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