{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:16:13Z","timestamp":1787922973569,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>GS\u2010441524 is a key antiviral agent for the treatment of feline infectious peritonitis (FIP), yet no authorized veterinary medicinal product is currently available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide a quality\u2010assured alternative to unregulated products, we developed a 50 mg\/mL oral suspension and evaluated its physicochemical stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three independent batches were prepared using Syrspend SF pH 4.0 and a veterinary flavouring agent. Stability was assessed at 5\u00b0C, 25\u00b0C\/60% RH and 40\u00b0C\/75% RH (transport simulation) over 12 weeks. In\u2010use stability was evaluated for 28 days following repeated withdrawals. Stability was defined as maintenance of drug concentration within 90%\u2013110% of initial values (45\u201355 mg\/mL), pH 3.5\u20134.5 and relative density 1.02\u20131.04 g\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All batches remained within predefined acceptance limits under all conditions. The formulation, therefore enables accurate oral dosing of GS\u2010441524 for weight\u2010adjusted therapy and provides a regulated alternative to unlicensed products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the suitability of the formulation as an extemporaneously compounded preparation under veterinary supervision. Pharmacokinetic and clinical performance were not assessed and should be addressed in future studies to further substantiate therapeutic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.71073","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:48:16Z","timestamp":1782809296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Physicochemical Stability of an Oral GS\u2010441524 Suspension for Weight\u2010Adjusted Treatment of Feline Infectious Peritonitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8951-6753","authenticated-orcid":false,"given":"C\u00e9dric","family":"Wernli","sequence":"first","affiliation":[{"name":"Private University in the Principality of Liechtenstein (UFL)  Triesen Liechtenstein"},{"name":"Lehenmatt\u2010Apotheke AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Streit","sequence":"additional","affiliation":[{"name":"Dr. E. Graeub AG  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2478\/afpuc\u20102018\u20100007"},{"key":"e_1_2_12_3_1","first-page":"319","article-title":"Antimicrobial Effectiveness and Physicochemical Stability of Compounded Psychiatric and Neurological Drug Suspensions in SyrSpend\u00ae SF PH4","volume":"29","author":"Kegele C. S.","year":"2025","journal-title":"International Journal of Pharmaceutical Compounding"},{"key":"e_1_2_12_4_1","first-page":"310","article-title":"Antimicrobial Stability, pH, and Physical Appearance of Cardiovascular Drug Suspensions in SyrSpend\u00ae SF PH4: A Complementary Evaluation","volume":"29","author":"Kegele C. S.","year":"2025","journal-title":"International Journal of Pharmaceutical Compounding"},{"key":"e_1_2_12_5_1","first-page":"409","article-title":"Microbiological and Physical Stability of Extemporaneous Oral Suspensions Compounded With SyrSpend\u00ae SF PH4","volume":"29","author":"Kegele C. S.","year":"2025","journal-title":"International Journal of Pharmaceutical Compounding"},{"key":"e_1_2_12_6_1","first-page":"222","article-title":"Physicochemical and Microbiological Stability of Commonly Prescribed APIs in SyrSpend\u00ae SF PH4: A Comprehensive Compatibility Study","volume":"29","author":"Kegele C. S.","year":"2025","journal-title":"International Journal of Pharmaceutical Compounding"},{"key":"e_1_2_12_7_1","first-page":"420","article-title":"SyrSpend\u00ae SF PH 4 as a Safe Vehicle for Extemporaneous Oral Suspensions: Microbiological Stability of Seven APIs","volume":"29","author":"Kegele C. 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