{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:53:15Z","timestamp":1791175995553,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myxomatous mitral valve disease (MMVD), the most common heart disease in small\u2010breed dogs, is characterized by mitral regurgitation (MR) resulting from valvular degeneration, which may progress to left\u2010sided heart failure. This report describes the cases of three dogs with severe MMVD (American College of Veterinary Internal Medicine Stages C or D) who exhibited an unexpected spontaneous reduction in MR despite continued valve degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>Three dogs initially presented with symptoms of heart failure and left atrial and ventricular enlargement. Standard treatment, including diuretics, improved their conditions; however, further monitoring revealed that the coaptation gap decreased due to mitral valve thickening, leading to a reduction in MR. This was accompanied by a significant decrease in heart size. As a result, diuretics were discontinued, and all dogs were successfully managed with pimobendan alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our knowledge, this is the first report of spontaneous MR reduction in MMVD, where coaptation gap narrowing played a role in clinical improvement. These cases may broaden the current understanding of MMVD progression, suggesting that, in rare instances, changes in cardiac remodelling and clinical status can occur. Further research is warranted to better understand the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.71155","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:30:12Z","timestamp":1791174612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Reduction in Mitral Valve Regurgitation in Three Dogs With Severe Myxomatous Mitral Valve Disease: An Unusual Case Report"],"prefix":"10.1002","volume":"12","author":[{"given":"Hyo\u2010Seung","family":"Nam","sequence":"first","affiliation":[{"name":"Dasom Animal Medical Center  Busan Republic of Korea"},{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute for Veterinary Biomedical Science Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-2458","authenticated-orcid":false,"given":"Yein","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute for Veterinary Biomedical Science Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.520"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.04.021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2012.02.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15488"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14068"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2017.07.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70050-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2015.13.1.17"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16131"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-017-0687-0"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.71155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:30:24Z","timestamp":1791174624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.71155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/vms3.71155"],"URL":"https:\/\/doi.org\/10.1002\/vms3.71155","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71155"}}