{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:55:22Z","timestamp":1791204922955,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tracheal collapse is a common canine respiratory disease characterized by dorsoventral cartilage flattening, airway lumen narrowing and subsequent mucosal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To investigate the efficacy of EAB\u2010277, a marine lipid extract combining\n                      <jats:italic>Perna canaliculus<\/jats:italic>\n                      (30\u00a0mg) and\n                      <jats:italic>Euphausia superba<\/jats:italic>\n                      (20\u00a0mg) as an adjunctive therapy in the management of tracheal collapse in dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one dogs with confirmed tracheal collapse were randomly assigned to receive standard conventional medications plus either EAB\u2010277 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021) or a placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020). The EAB\u2010277 treatment protocol included a loading dose for the initial 14 days. Clinical signs and quality of life were assessed together with fluoroscopy, radiography, haematology and serum biochemistry on Days 0, 14, 28 and 56.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs receiving EAB\u2010277 showed a significant improvement in exercise tolerance by Day 14. Concurrently, fluoroscopic analysis demonstrated significant reductions in the percentage change in tracheal luminal diameter across the cervical, thoracic inlet and intrathoracic regions by Day 14. Both groups showed significant improvements in cough scores throughout the study, with no statistical difference between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although conventional medical therapy effectively manages the clinical signs of tracheal collapse, particularly cough, this study demonstrates that EAB\u2010277 provides additional benefits by significantly improving exercise tolerance and reducing dynamic tracheal collapse at the cervical, thoracic inlet and intra\u2010thoracic regions, which might have the potential to enhance airway health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.71159","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:44:46Z","timestamp":1786722286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Therapy With a\n                    <i>Perna canaliculus<\/i>\n                    and\n                    <i>Euphausia superba<\/i>\n                    Extract (EAB\u2010277\n                    <sup>TM<\/sup>\n                    ) for Clinical Signs of Tracheal Collapse in Dogs: A Prospective, Randomized and Placebo\u2010Controlled Exploratory Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1371-3092","authenticated-orcid":false,"given":"Wasutorn","family":"Yangwanitset","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0395-6610","authenticated-orcid":false,"given":"Somkiat","family":"Huaijantug","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Public Health, Faculty of Veterinary Science Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6952-0536","authenticated-orcid":false,"given":"Mookmanee","family":"Taechikantaphat","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Public Health, Faculty of Veterinary Science Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-6161","authenticated-orcid":false,"given":"Melanie","family":"Hezzell","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-9506","authenticated-orcid":false,"given":"Walasinee","family":"Sakcamduang","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Public Health, Faculty of Veterinary Science Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1986.47.05.1002"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2013.06.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.08.010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.22.03.0108"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.05.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.5.909"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02551.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.11.003"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/608438"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00510-2021"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0150.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01051.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2005.00024.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50306-0"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.4.1344"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422060153"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-136"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0451.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13612"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15488"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1448249"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.01.013"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.07.003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.8.986"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.12.1870"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.09.004"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(92)50302-3"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.880952"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(99)80017-6"},{"key":"e_1_2_13_31_1","first-page":"195","article-title":"The Epidemic of Canine Obesity and Its Role in Osteoarthritis","volume":"67","author":"Sanderson S.","year":"2012","journal-title":"Israel Journal of Veterinary Medicine"},{"key":"e_1_2_13_32_1","first-page":"24","article-title":"Fluoroscopic and Radiographic Assessment of Variations in Tracheal Height During Inspiration and Expiration in Healthy Adult Small\u2010Breed Dogs","volume":"84","author":"Scherf G.","year":"2020","journal-title":"Canadian Journal of Veterinary Research = Revue canadienne de recherche v\u00e9t\u00e9rinaire"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1982.tb00691.x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12436"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12349"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.049767"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2110-7"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12344"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13091434"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.71159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:28:19Z","timestamp":1791203299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.71159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/vms3.71159"],"URL":"https:\/\/doi.org\/10.1002\/vms3.71159","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2025-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71159"}}