{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:54:36Z","timestamp":1791204876042,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Foot\u2010and\u2010Mouth Disease (FMD) is a highly contagious viral disease that poses a severe threat to global livestock production and food security. In Ethiopia, the disease is endemic, with multiple circulating serotypes (O, A, SAT1, and SAT2) significantly impacting the agricultural economy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the seroprevalence of FMD across livestock populations in Ethiopia and identify associated risk factors to inform effective, evidence\u2010based control strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional surveillance study was conducted between 2016 and 2023. A total of 19,699 serum samples were collected from cattle, sheep, and goats across all regional states using a systematic sampling design. Antibodies against the FMD virus 3ABC protein were detected using Non\u2010Structural Protein (NSP) ELISA. Data were analysed using descriptive statistics, univariable analysis, and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall FMD seroprevalence was 22% (4,341\/19,699). Prevalence varied significantly by region, with the highest in Gambella (56.8%), followed by SNNPR (25.6%) and Oromia (23.7%), and the lowest in Amhara (14.6%). By species, cattle (23.9%) and sheep (22.3%) exhibited higher infection rates compared to goats (5.6%). Regional location (specifically Gambella) was identified as a significant risk factor (OR: 1.31; 95% CI: 0.36\u20130.49).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings confirm the endemic nature of FMD across all Ethiopian regional states and production systems. Cattle serve as the primary maintenance species, with age, species, and regional movement patterns acting as key drivers of viral circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recommendations<\/jats:title>\n                    <jats:p>There is an urgent need for risk\u2010based surveillance and targeted vaccination strategies, particularly along major livestock trade routes and in districts with intensive inter\u2010herd mixing. Implementing these spatially and epidemiologically informed control measures is essential to reducing the burden of FMD, protecting pastoralist livelihoods, and enhancing national food security and livestock export potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.71227","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:58:55Z","timestamp":1789091935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence and Associated Risk Factors of Foot\u2010and\u2010Mouth Disease in Livestock in Ethiopia: Findings From a National Surveillance (2016\u20132023)"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-9954","authenticated-orcid":false,"given":"Daniel","family":"Gizaw","sequence":"first","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagos","family":"Asgdom","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-3876","authenticated-orcid":false,"given":"Ayelech","family":"Muluneh","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayenalem","family":"Fentie","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-2480","authenticated-orcid":false,"given":"Demessa","family":"Negessu","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genet","family":"Bogale","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-5920","authenticated-orcid":false,"given":"Takele","family":"Worku","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5617-6174","authenticated-orcid":false,"given":"Ashebir","family":"Abebe","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getnet Abie","family":"Mekonnen","sequence":"additional","affiliation":[{"name":"Animal Health Institute (AHI)  Sebeta Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.02.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.31.3.2153"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"79","article-title":"Sero\u2010Prevalence of Bovine Foot\u2010and\u2010Mouth Disease in Selected Districts of Eastern Showa Zone, Oromia Regional State, Ethiopia","volume":"16","author":"Belina D.","year":"2016","journal-title":"Global Journal of Science Frontier Research"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.34.3.2407"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"30","article-title":"Ethiopian Livestock Sector Current Status and Future Prospects Introduction: Livestock Production","volume":"6","author":"CSA","year":"2016","journal-title":"Journal of Biology, Agriculture and Healthcare"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"63","article-title":"Combining Livestock Trade Patterns With Phylogenetics to Help Understand the Spread of Foot and Mouth Disease in sub\u2010Saharan Africa, the Middle East and Southeast Asia","volume":"30","author":"Di Nardo A.","year":"2011","journal-title":"Revue scientifique et technique (International Office of Epizootics)"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"405","article-title":"Assessment of the Role of Livestock in Ethiopia: A Review","volume":"11","author":"Endalew B.","year":"2016","journal-title":"Journal of Scientific Research"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"5","article-title":"Seroprevalence of Foot and Mouth Disease in Bench Maji Zone, Southwestern Ethiopia","volume":"1","author":"Gelaye E.","year":"2009","journal-title":"Journal of Veterinary Medicine and Animal Health"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.13675"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12338"},{"key":"e_1_2_11_12_1","unstructured":"Knowles N.2020.FAO World Reference Laboratory for Foot\u2010and\u2010Mouth Disease (WRLFMD) Genotyping Report. WRLFMD."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1112.050908"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-012-0339-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-008-9276-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5210\/ojphi.v10i1.8648"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2010.01154.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-007-9049-6"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4102\/ojvr.v74i4.115"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1429-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4314\/evj.v20i1.4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010023\u201002263\u20100"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.71227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:26:11Z","timestamp":1791203171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.71227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/vms3.71227"],"URL":"https:\/\/doi.org\/10.1002\/vms3.71227","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71227"}}