{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:41:25Z","timestamp":1792590085508,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine & Sci"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Allergic otitis externa is common in dogs and recurrence may lead to repeated consultations and antimicrobial use. Long\u2010term data on proactive topical corticosteroid maintenance are limited.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To describe 12\u2010month relapse frequency in dogs with allergic otitis externa receiving proactive hydrocortisone aceponate maintenance therapy and compare consecutive\u2010day and non\u2010consecutive\u2010day schedules.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Medical records of client\u2010owned dogs prescribed hydrocortisone aceponate ear spray were retrospectively reviewed. Maintenance started after clinical and cytological remission. Only dogs with confirmed continuation, stable concomitant allergy management and complete 12\u2010month outcome data were included. Relapse was defined as recurrent otitis externa requiring veterinary examination, cytology and additional otic treatment. Dogs were grouped by schedule: Protocol 1, two consecutive days; and Protocol 2, two non\u2010consecutive days weekly. Outcomes were compared using Fisher exact and Mann\u2013Whitney\n U<\/jats:italic>\n tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010one dogs were included; 36 in Protocol 1 and 35 received Protocol 2. During 12 months, 50\/71 dogs (70.4%) had no relapse, 12\/71 (16.9%) had one relapse and 9\/71 (12.7%) had multiple relapses. At least one relapse occurred in 9\/36 dogs (25.0%) in Protocol 1 and 12\/35 (34.3%) receiving Protocol 2 (\n p<\/jats:italic>\n = 0.443). Multiple relapses occurred in 2\/36 (5.6%) and 7\/35 (20.0%) dogs, respectively (\n p<\/jats:italic>\n = 0.085). Relapse counts did not differ significantly between protocols (\n p<\/jats:italic>\n = 0.290).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Most dogs had no relapse or only one relapse during proactive hydrocortisone aceponate maintenance. No statistically significant difference was detected between schedules, but equivalence or non\u2010inferiority cannot be concluded.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vms3.71276","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:58:00Z","timestamp":1792587480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proactive Treatment of Canine Allergic Otitis Externa With Hydrocortisone Aceponate: A Retrospective Observational Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8255-0563","authenticated-orcid":false,"given":"Elisa","family":"Maina","sequence":"first","affiliation":[{"name":"Division of Clinical Dermatology Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3405-7695","authenticated-orcid":false,"given":"Jasmine Chantale","family":"Rigert","sequence":"additional","affiliation":[{"name":"Division of Clinical Dermatology Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Filippini","sequence":"additional","affiliation":[{"name":"Division of Clinical Dermatology Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regula","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Clinical Dermatology Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7893-7520","authenticated-orcid":false,"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine CIISA \u2013 Centre for Interdisciplinary Research in Animal Health University of Lisbon Lisbon Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS) Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/vde.70008","article-title":"Hydrocortisone Aceponate for Chronic Otitis: Long\u2010Term Efficacy","volume":"36","author":"Lorente\u2010M\u00e9ndez C.","year":"2025","journal-title":"Veterinary Dermatology"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/vde.12285","article-title":"Efficacy of Proactive Long\u2010Term Maintenance Therapy of Canine Atopic Dermatitis With 0.0584% Hydrocortisone Aceponate Spray: A Double\u2010Blind Placebo Controlled Pilot Study","volume":"27","author":"Louren\u00e7o A. M.","year":"2016","journal-title":"Veterinary Dermatology"},{"issue":"2","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4142\/jvs.2012.13.2.187","article-title":"Evaluation of the Effect of a 0.0584% Hydrocortisone Aceponate Spray on Clinical Signs and Skin Barrier Function in Dogs With Atopic Dermatitis","volume":"13","author":"Nam E. H.","year":"2012","journal-title":"Journal of Veterinary Science"},{"issue":"1","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.2460\/javma.23.01.0002","article-title":"Managing Recurrent Otitis Externa in Dogs: What Have We Learned and What Can We Do Better?","volume":"261","author":"Nuttall T.","year":"2023","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"3","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-3164.2009.00756.x","article-title":"Efficacy of a 0.0584% Hydrocortisone Aceponate Spray in the Management of Canine Atopic Dermatitis: A Randomised, Double Blind, Placebo\u2010Controlled Trial","volume":"20","author":"Nuttall T.","year":"2009","journal-title":"Veterinary Dermatology"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-3164.2011.00992.x","article-title":"Comparable Efficacy of a Topical 0.0584% Hydrocortisone Aceponate Spray and Oral Ciclosporin in Treating Canine Atopic Dermatitis","volume":"23","author":"Nuttall T. J.","year":"2012","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12917-015-0514-6","article-title":"Treatment of Canine Atopic Dermatitis: 2015 Updated Guidelines From the International Committee on Allergic Diseases of Animals","volume":"11","author":"Olivry T.","year":"2015","journal-title":"BMC Veterinary Research"},{"issue":"2","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/vde.13224","article-title":"Efficacy and Safety of a Hydrocortisone Aceponate\u2010Containing Ear Spray Solution in Dogs With Erythemato\u2010Ceruminous Otitis Externa: A Randomised, Multicentric, Single\u2010Blinded, Controlled Trial","volume":"35","author":"Rigaut D.","year":"2024","journal-title":"Veterinary Dermatology"},{"issue":"2","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cvsm.2003.10.006","article-title":"Causes of Otitis Externa","volume":"34","author":"Rosser E. J.","year":"2004","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"issue":"2","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/vde.12909","article-title":"Efficacy and Safety of 0.0584% Hydrocortisone Aceponate Topical Spray and Systemic Oclacitinib Combination Therapy in Dogs With Atopic Dermatitis: A Randomized, Double\u2010Blinded, Placebo\u2010Controlled Trial","volume":"32","author":"Takahashi J.","year":"2021","journal-title":"Veterinary Dermatology"},{"issue":"9596","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies","volume":"370","author":"Elm E.","year":"2007","journal-title":"Lancet"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.71276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.71276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:58:02Z","timestamp":1792587482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.71276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/vms3.71276"],"URL":"https:\/\/doi.org\/10.1002\/vms3.71276","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71276"}}