{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:39:56Z","timestamp":1792589996537,"version":"4.5.0"},"reference-count":171,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Long non\u2010coding RNAs (lncRNAs) have emerged as critical regulators of economically important traits in livestock, including growth, reproduction, disease resistance and product quality. Unlike protein\u2010coding genes, lncRNAs orchestrate gene expression at epigenetic, transcriptional and post\u2010transcriptional levels, acting as molecular switches, scaffolds, decoys, and competing endogenous RNAs (ceRNAs). This review synthesises current knowledge on key lncRNA mechanisms such as ceRNA networks, liquid\u2013liquid phase separation (LLPS) and RNA\u2010targeting clustered regularly interspaced short palindromic repeats (CRISPR\u2010Cas13) screening alongside trait\u2010specific case studies in muscle hypertrophy (Callipyge locus), embryonic development (lnc_2217 in goats) and fecundity (ceRNA networks in sheep and chickens). We highlight the integration of lncRNAs with Genome Wide Association Studies (GWAS) data, where over 90% of trait\u2010associated variants reside in non\u2010coding regions, and propose a practical roadmap for functional validation and incorporation of lncRNAs into genomic selection and breeding programs. Harnessing lncRNA biology supported by recent functional annotation of animal genomes (FAANG) epigenomic maps and CRISPR\u2010Cas13 applications in livestock, researchers will accelerate genetic gain in growth rate, marbling score, litter size and disease resilience, marking a paradigm shift toward precision livestock breeding.<\/jats:p>","DOI":"10.1002\/vms3.71292","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:50:12Z","timestamp":1792587012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long Non\u2010Coding RNAs: Key Regulators of Economic Traits in Livestock From Mechanisms to Breeding Applications"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9489-7704","authenticated-orcid":false,"given":"Keyvan","family":"Khani","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture University of Zanjan  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taher","family":"Harkinezhad","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture University of Zanjan  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahimeh","family":"Sepehri","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture University of Zanjan  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fcell.2019.00377","article-title":"Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate","volume":"7","author":"Arnold P. 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