{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:35:53Z","timestamp":1777397753526,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Coccidiosis is the most common enteric parasitic disease in poultry that is caused by different species of\n                      <jats:italic>Eimeria<\/jats:italic>\n                      . Some chemical drugs were utilized for the control of this infection but drug residue and resistance\u2010induced concerns in chicken consumers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study was performed to evaluate the effect of pomegranate peel extract (PPEx) on the control of coccidiosis in chickens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Totally, 300 broiler chicks were divided into 10 groups and 5 groups challenged with a mixture of common\n                      <jats:italic>Eimeria<\/jats:italic>\n                      of 21 days old in Iran. Five days after the challenge, as soon as clinical signs appeared, the oocyte per gram (OPG) of faeces was measured, and chickens were treated with 100, 200 and 400\u00a0ppm PPEx (for 7 days) and toltrazuril (for 2 days) in separate groups. Another five groups were only treated with these compounds without challenge. All challenged and non\u2010challenged have a control group. The OPG was measured in the final treatment in chickens. At 35 days of age, all chickens were euthanized and the intestinal and liver samples were collected in 10% formalin for histopathological examination. The growth indices were recorded and analysed all over the growing period, weekly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results revealed that the addition of PPEx especially in 400\u00a0ppm can reduce the intestinal lesions and OPG but in this dose, the growth indices can influence negatively, while the administration of toltrazuril with the best effect on OPG and intestinal lesions, no effect on growth indices in challenged chickens. Also, supplementation of 400\u00a0ppm PPEx can induce injuries in the liver while the lower dose has no effect on liver tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is necessary for finding effective ingredients in PPEx and preparation of serial dilution for access to optimal dose with best anti\u2010coccidial effect and lowest negative effect on growth indices in chickens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.714","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:24:07Z","timestamp":1641273847000},"page":"635-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The efficacy of pomegranate peel extract on\n                    <i>Eimeria<\/i>\n                    shedding and growth indices in experimental coccidiosis in broiler chickens"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-4514","authenticated-orcid":false,"given":"Pedram","family":"Khorrami","sequence":"first","affiliation":[{"name":"Graduated of Veterinary Medicine Faculty Shahrekord Branch Islamic Azad University  Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-1091","authenticated-orcid":false,"given":"Majid","family":"Gholami\u2010Ahangaran","sequence":"additional","affiliation":[{"name":"Department of Poultry Diseases Faculty of Veterinary Medicine Shahrekord Branch Islamic Azad University  Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-5104","authenticated-orcid":false,"given":"Elham","family":"Moghtadaei\u2010Khorasgani","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine Shahrekord Branch Islamic Azad University  Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.05.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.13005\/bbra\/2010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.08.018"},{"key":"e_1_2_9_5_1","first-page":"53","volume-title":"Manual of histological techniques and their diagnostic application","author":"Bancroft J. 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