{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:46:24Z","timestamp":1774017984615,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this report is to document the case of a dog that developed pleural effusion as a potential side\u2010effect to the administration of a high\u2010dose of amlodipine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A Yorkshire terrier dog (13\u2010year\u2010old, castrated male, 4.5\u00a0kg) presented with severe systemic hypertension\u00a0(&gt;200\u00a0mmHg), hyperkalaemia, and acute pancreatitis. The dog had hyperadrenocorticism, chronic valvular heart disease, chronic kidney disease, and cerebellar infarction as underlying diseases. Additionally, the dog had laboured breathing and tachypnoea during hospitalization. Screening examinations revealed a pleural effusion (pure transudate) for which hypoalbuminemia and thromboembolism were ruled out as the causes. Therefore, the adverse drug event of an anti\u2010hypertensive drug (amlodipine) was tentatively diagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pleural effusion resolved within 24\u00a0h of reducing the dosage of amlodipine. Hence, the dog was diagnosed with amlodipine\u2010induced pleural effusion. Rarely, amlodipine can cause pleural effusion after high\u2010dose administrations in humans, but only two cases of peripheral edema have been reported in animals. If pleural effusion occurs in hypertensive patients administered amlodipine, it should be considered as the potential cause.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.727","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T04:42:14Z","timestamp":1644295334000},"page":"445-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension"],"prefix":"10.1002","volume":"8","author":[{"given":"Hee\u2010Won","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo\u2010young","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyuyong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mincheol","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hyun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung\u2010Kyu","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-2458","authenticated-orcid":false,"given":"Ye\u2010In","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-1348","authenticated-orcid":false,"given":"Hwa\u2010Young","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.4.383"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02107.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5558"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2016.1301"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.11.1441"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.d.17.00071"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/546012"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"1024","article-title":"Non\u2010cardiogenic pleural effusion after amlodipine intoxication and hyperinsulinemic therapy","volume":"5","author":"Karaca O.","year":"2016","journal-title":"Medicine"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.15746\/sms.15.055"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199507000-00016"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"397","article-title":"Update on the use of trilostane in dogs","volume":"59","author":"Lemetayer J.","year":"2018","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_11_14_1","volume-title":"Vasodilatory edema: A common side effect of antihypertensive therapy","author":"Messerli F. 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