{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:16:51Z","timestamp":1791980211612,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Leukaemia cutis (LC) is the infiltration of neoplastic leukocytes into the skin, characterised by haemorrhagic papules, nodules, and plaques. LC has been reported in human leukaemia patients, but it is extremely rare in dogs. A 13\u2010year\u2010old spayed female Golden Retriever that was previously diagnosed with chronic lymphocytic leukaemia was managed with chlorambucil (20\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    orally, every 2\u00a0weeks) and prednisolone (2\u00a0mg\/kg orally, every other day) for 8 months; however, immunosuppression was temporarily discontinued because of a bacterial urinary tract infection. Cutaneous signs, including multifocal ecchymosis and white plaques, appeared 1 month after cessation of chemotherapy. Histopathological examination revealed small\u2010 to intermediate\u2010sized lymphocytes with mild atypia in a perivascular to interstitial pattern within the superficial dermis. The bands of atypical cells within the superficial dermis were strongly and extensively positive for CD3 on immunohistochemistry. Polymerase chain reaction analysis of the biopsied skin revealed clonal rearrangement of the T\u2010cell receptor gamma locus gene. Given the evidence of clinical signs, peripheral immunophenotyping, histopathology, immunohistochemistry, and clonal gene arrangement, LC was diagnosed. The lesions disappeared when chemotherapy was restarted but were occasionally observed when chemotherapy was stopped. To the authors\u2019 best knowledge, this is the first case report of LC in a dog.\n                  <\/jats:p>","DOI":"10.1002\/vms3.749","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T05:33:10Z","timestamp":1643607190000},"page":"947-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of leukaemia cutis in a dog with T\u2010cell chronic lymphocytic leukaemia"],"prefix":"10.1002","volume":"8","author":[{"given":"Hyeona","family":"Bae","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Seon","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulsoo","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-6006","authenticated-orcid":false,"given":"Dong\u2010In","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinho","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Industrial Science Kongju National University  Yesan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-6926","authenticated-orcid":false,"given":"DoHyeon","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102303.2006.00289.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102230.2002.01018.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000139738"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2010.01623.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199608000\u201000009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/WYACYWF6NGM3WBRT"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1024533021000008164"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.1998.tb01779.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103164.2009.00793.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.3.293"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.060"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.02.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327489800500102"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.1997.tb00821.x"},{"key":"e_1_2_9_16_1","volume-title":"Muller and Kirk's small animal dermatology","author":"Miller W. 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