{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:14:00Z","timestamp":1772118840908,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005362","name":"Universita degli Studi di Bari Aldo Moro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aminogam gel is used in human patients to accelerate the post\u2010surgical wound healing process of soft oral tissues (e.g. after teeth extraction or oral laser surgery). For this reason and because of the histological affinity between oral and genital mucosa, Aminogam Gel was applied on the dog's penile mucosa to evaluate wound healing after traumatic lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare conventional therapy (using only oral medications) to topic application of \u2018Aminogam Gel\u2019 in order to determine which is better to accelerate the healing process of canine penis injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For this study, 12 male dogs with an injured penis and traumatic paraphimosis were selected. All patients had traumatic penis injuries due to unsuccessful mating attempts and consequent trauma (continuous licking). The dogs underwent surgical curettage of necrotic areas. The animals were randomly divided into two groups: a control group treated with routine therapy and a group treated with Aminogam Gel as an adjuvant for the scarring process. We assessed wound status and tracked healing using the Bates\u2010Jensen Wound Assessment Tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs treated with Aminogam Gel therapy healed faster than dogs treated with traditional therapy alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Aminogam Gel is a valid auxiliary drug to accelerate wound healing after penis surgery. This is especially important for breeding dogs, for whom rapid and complete healing of the penis is important for returning to normal reproductive activities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.769","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:39:57Z","timestamp":1646113197000},"page":"1001-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Use of \u2018Aminogam Gel\u2019 to fast the wound healing in dogs after the surgical curettage of injured penis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-8848","authenticated-orcid":false,"given":"Vincenzo","family":"Cicirelli","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Accogli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Caira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovani M","family":"Lacalandra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Aiudi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Bari \u2018Aldo Moro\u2019  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-016-9666-2"},{"key":"e_1_2_11_3_1","first-page":"475","volume-title":"Current techniques in small animal surgery","author":"Birchard S. 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Cannavale R.&Vicidomini A.(2009). \u201dLa Rigenerazione Tissutale E Le Mucositi\u201d Congresso Nazionale Dei Docenti Di Discipline Odontostomatologiche E Chirurgia Maxillo Facciale (pp. 12\u201315)."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.05.010"},{"key":"e_1_2_11_18_1","first-page":"534","volume-title":"Current techniques in small animal surgery","author":"Fowler D. J.","year":"1998"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2018.01.019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0b013e3181d73aab"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.01.006"},{"key":"e_1_2_11_22_1","unstructured":"Majorana A.&Cagetti M. G.(2009). Le Lesioni Delle Mucose Orali Nel Bambino: Dalle Linee Guida Nazionali Ministeriali Di Prevenzione Alla Terapia Con Impiego Di Acido Jaluronico E Amminoacidi. Congresso Nazionale Dei Docenti Di Discipline Odontostomatologiche E Chirurgia Maxillo Facciale (pp. 28\u201330)."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200902200225"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.094"},{"key":"e_1_2_11_25_1","first-page":"1","article-title":"CDC national hospital ambula\u2010tory medical care survey","volume":"386","author":"Nawar E. W.","year":"2005","journal-title":"Emergency Department Summary"},{"key":"e_1_2_11_26_1","unstructured":"Pope E. R.(1997). Surgery of the penis prepuce and scrotum. ACVS Veterinary Symposium (pp. 492\u2013494)."},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sm2.54"},{"issue":"2","key":"e_1_2_11_28_1","first-page":"109","article-title":"Accelerated wound healing of oral soft tissues and angiogenic effect induced by a pool of aminoacids combined to sodium hyaluronate (aminogam)","volume":"22","author":"Ribatti D.","year":"2008","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2013.3509"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(01)50203-X"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05472-0.00056-6"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707253"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjps.tjps_5_18"},{"key":"e_1_2_11_34_1","unstructured":"Vescovi P.&Manfrei M.(2009). 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