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Nanomaterials have exceptional physicochemical characteristics, including increased intestinal absorption, biodistribution, bioavailability, and improved antimicrobial and catalytic properties. Although nanotechnology is gaining ground in animal management, husbandry, and production, its wide use is still hampered by occasional toxicity and side effects. Zinc oxide nanoparticles (ZnO\u2010NPs) have long been utilized in animal production, aquaculture, and pet animal medicine. However, the use ZnO\u2010NPs in animals has been associated with reports of toxicity and side effects. ZnO\u2010NPs may have shown numerous beneficial effects in animals; its use must be regulated with care to avoid unwanted consequences. Thus, this review emphasizes the usage of ZnO\u2010NPs in animal production and laboratory animals and the potential side effects associated with the use of nanoparticles as a feed supplement and therapeutic compound.<\/jats:p>","DOI":"10.1002\/vms3.814","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T17:09:01Z","timestamp":1652980141000},"page":"1769-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Beneficial and toxicological aspects of zinc oxide nanoparticles in animals"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-0399","authenticated-orcid":false,"given":"Heshu Sulaiman","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Physiology College of Medicine University of Sulaimani  Sulaimaniyah Republic of Iraq"},{"name":"Department of Medical Laboratory Sciences Komar University of Science and Technology  Sulaimaniyah Republic of Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemn Hassan","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy University of Sulaimani  Sulaimaniyah Republic of Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasedee","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Veterinary Laboratory Diagnosis Faculty of Veterinary Medicine Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareth Yahya Ahmed Shujaa","family":"Edin","sequence":"additional","affiliation":[{"name":"Institute of Bioscience Universiti Putra Malaysia  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagi A.","family":"AL\u2010Haj","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Sana'a University  Sana'a 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