{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:46Z","timestamp":1772119006366,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Foot\u2010and\u2010mouth disease (FMD) is an economically important animal disease because of the speed of its transmission. Routine vaccination may not be effective; RAM can be considered as a potential facilitator for this. Present study was designed to evaluate the effects of feeding different treatment of the RAM in different days on the immune responses in mice immunised with FMDV type O vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>In experiment 1, 50 ICR mice were randomly divided into five groups with 10 animals in each group, and the basic diet containing 1% Crush of RAM for 1\u2010week ad libitum feeding period, 1% Crush of RAM for 6\u2010week ad libitum feeding period, 1% Decoction of RAM for a 1\u2010week ad libitum feeding period, 1% Decoction of RAM for a 6\u2010week ad libitum feeding period, respectively. Blood samples were collected 2\u00a0weeks after boosting for measurement of FMDV\u2010specific IgG level and the IgG subclasses, lymphocyte proliferation as well as production IL\u20105 and IFN\u2010\u03b3. In experiment 2, four groups mice were fed basic diet and basic diet containing 5% Decoction of RAM for 2\u2010, 4\u2010 and 6\u2010day ad libitum feeding periods, respectively. Then we collected blood samples for detecting IgG and IgG subclasses, splenocytes for lymphocyte proliferation as well as production IL\u20105 and IFN\u2010\u03b3, and tissue samples of small intestine for sIgA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicated that 1% Decoction of RAM for a 1\u2010week ad libitum feeding period group and 5% Decoction of RAM for 2\u2010, 4\u2010 and 6\u2010day ad libitum feeding period group enhance the FMDV\u2010specific immune responses significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, the results demonstrate that doses and feeding time of RAM are important to affect the immune responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.871","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T16:38:33Z","timestamp":1660840713000},"page":"2067-2075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of the extract made from\n                    <i>Rhizoma Atractylodis Macrocephalae<\/i>\n                    (RAM) on the immune responses of mice to a commercial foot\u2010and\u2010mouth disease vaccine"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-2626","authenticated-orcid":false,"given":"Ming","family":"Qin","sequence":"first","affiliation":[{"name":"Yantai Academy of Agricultural Sciences Institute of Animal Science and Veterinary Medicine  Yantai Shandong Province P.\u00a0R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiewei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Jiangxi Agriculture University  Nanchang Jiangxi Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedsirin","family":"Sakwiwatkul","sequence":"additional","affiliation":[{"name":"Faculty of Technology, Department of Agriculture Technology Mahasarakham University Kantarawichai District Maha Sarakham Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiangxi Academy of Agricultural Sciences Institute of Quality &amp; Safety and Standards for Agricultural Products  Nanchang Jiangxi Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Chang","sequence":"additional","affiliation":[{"name":"Jiangxi Academy of Agricultural Sciences Institute of Quality &amp; Safety and Standards for Agricultural Products  Nanchang Jiangxi Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengbo","family":"Chi","sequence":"additional","affiliation":[{"name":"Laiyang Agrotechnical Extension Center  Yantai Shandong Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutao","family":"Li","sequence":"additional","affiliation":[{"name":"Weifang Academy of Agricultural Sciences Institute of Animal Science  Weifang Shandong Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruili","family":"Li","sequence":"additional","affiliation":[{"name":"Yantai Academy of Agricultural Sciences Institute of Animal Science and Veterinary Medicine  Yantai Shandong Province P.\u00a0R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173735"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(87)80009-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.07.116"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/972083"},{"issue":"19","key":"e_1_2_10_6_1","first-page":"1272","article-title":"Enhancement of the immune responses to ovalbumin in mice by oral administration of the extract from Radix Cyathulae (RC)","volume":"7","author":"Feng H.","year":"2013","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028696"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4041873"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4393"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.02.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.995652"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.2.449"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-45-3-761"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.159467"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.05.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.3943"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.03.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.03.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/926381"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.04.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.09.080"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.075"},{"issue":"10","key":"e_1_2_10_23_1","first-page":"1012","article-title":"Advances in research on chemical constituents, pharmacological actions and processing of atractylodes macrocephala","volume":"31","author":"Ying Z.","year":"2017","journal-title":"Chinese Journal of Pharmacology and Toxicology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.023"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:25:16Z","timestamp":1692678316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/vms3.871"],"URL":"https:\/\/doi.org\/10.1002\/vms3.871","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.871\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.871\/v2\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,18]]},"assertion":[{"value":"2022-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}