{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:25:39Z","timestamp":1774034739352,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the potential intraocular pressure (IOP)\u2010lowering effects of nitric oxide (NO)\u2010donating compounds in healthy canine eyes<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 79 dogs were divided into 3 groups in a masked, controlled and randomised study. Group N (\n                      <jats:italic>n<\/jats:italic>\n                      = 26) was administered 0.03% nitroglycerin in one eye and vehicle\u2010control in the other, Group H (\n                      <jats:italic>n<\/jats:italic>\n                      = 26) was administered 0.1% hydralazine in one eye and vehicle\u2010control in the other, while Group C (\n                      <jats:italic>n<\/jats:italic>\n                      = 27) received vehicle\u2010control in both eyes (control group). Following eye drop administration, IOP was measured in both eyes at selected times (10\u2013250 min), along with monitoring of heart rate and signs of ocular discomfort. Data was analysed with repeated measures mixed model and one\u2010way ANOVA\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IOP was significantly reduced over the 4\u2010h period with 0.03% nitroglycerin (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001) but not 0.1% hydralazine (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.520) when compared to contralateral vehicle\u2010controlled eyes. IOP was reduced by up to 12% with 0.03% nitroglycerin from 10 to 70 min post\u2010treatment; however, differences in IOP at individual time points were not statistically significant for either drug (\n                      <jats:italic>p<\/jats:italic>\n                      \u2265 0.133) as compared to contralateral vehicle\u2010control eyes. No treatment group significantly affected heart rate (compared to Group C), and both treatment groups appeared well tolerated\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both compounds were well\u2010tolerated in healthy dogs. Nitroglycerin mildly reduced IOP in canine eyes, and further investigations are warranted in healthy and diseased states (e.g. glaucoma, ocular hypertension).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.945","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T17:03:28Z","timestamp":1663866208000},"page":"2367-2373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of topical nitric oxide donors 0.03% nitroglycerin and 0.1% hydralazine on intraocular pressure in healthy canine eyes"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-7883","authenticated-orcid":false,"given":"Parker A.","family":"Wilcox","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis D.","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Sebbag","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-7004","authenticated-orcid":false,"given":"Rachel A.","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S156038"},{"key":"e_1_2_11_3_1","first-page":"1711","article-title":"Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye","volume":"37","author":"Behar Cohen F. 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