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Cortisol levels after the adrenocorticotropic hormone stimulation test were within the therapeutic range, but aldosterone levels were below the reference range; hence, isolated hypoaldosteronism was diagnosed. After administration of deoxycorticosterone pivalate (DOCP), the electrolyte imbalance improved with a Na:K ratio of 27.7. This is the first report of the management of isolated hypoaldosteronism and hypercortisolism using trilostane and DOCP in a dog. This case highlights the importance of recognizing isolated hypoaldosteronism after long\u2010term treatment with trilostane in a canine patient with CKD.<\/jats:p>","DOI":"10.1002\/vms3.954","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T04:41:34Z","timestamp":1663216894000},"page":"2292-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism"],"prefix":"10.1002","volume":"8","author":[{"given":"Su\u2010Min","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hyun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Veterinary Emergency and Critical Care Medicine and Institute of Veterinary Science, College of Veterinary Medicine Kangwon National University  Chuncheon\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na\u2010Hyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010In","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung\u2010won","family":"Seo","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa\u2010Young","family":"Youn","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12955"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.7.781a"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00051.2001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2004.tb00241.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.14"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.10.007"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"699","article-title":"Canine iatrogenic persistent hypoadrenocorticism after short\u2010term treatment of hyperadrenocorticism with trilostane\u2014A case report","volume":"81","author":"G\u00f3jska\u2010Zygner O.","year":"2011","journal-title":"Veterinarski Arhiv"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12268"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14828"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.10.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00072.x"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"63","article-title":"Canine hypoadrenocorticism: Part I","volume":"51","author":"Klein S. 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