{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:00Z","timestamp":1772118960591,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005071","name":"Shiraz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowledge on possible delaying effects of topical ciprofloxacin on corneal ulcer healing is scarce in avian patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study evaluates effects of different dosage regimens of topical ciprofloxacin on healing of corneal ulcer in an avian model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and fifty adult layers were randomly allocated into two equal categories each consisted of 5 groups (\n                      <jats:italic>n<\/jats:italic>\n                      = 15): 1, negative control (NC, normal cornea); 2, positive control (PC) (birds with experimental corneal ulcer); and 3, 4 and 5, birds with corneal injury that received ciprofloxacin 0.3% topically q6h, q8h and q12h, respectively for 3 (category 1) or 5 days (category 2). Corneas were excised for histopathological evaluation and determination of MMP\u20109 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While no significant difference was observed in daily\u2010measured fluorescein\u2010stained ulcer size among ciprofloxacin\u2010treated birds and PC group in category 1, birds in PC group of category 2 had significantly smaller ulcers as compared to antibiotic\u2010treated birds at the end of experiment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01 for all cases). Histopathological evaluations at the end of the experiment showed no significant difference among PC and ciprofloxacin\u2010treated birds of both categories for almost all of the assayed parameters. Over expression of MMP\u20109 mRNA was observed in PC group after 3 and 5 days of ulcer induction compared to NC groups. Its expression in ciprofloxacin\u2010treated birds of both categories remained close to PC groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While ciprofloxacin administration for 3 days does not affect ulcer healing, it delays healing process at the end of 5 days of treatments in an avian model of corneal ulcer injury. This delaying effect is not associated with a drastic change in MMP\u20109 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.972","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T13:41:02Z","timestamp":1666014062000},"page":"999-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of delaying effects of different short\u2010term dosage regimens of topical ciprofloxacin on corneal ulcer healing in an avian model"],"prefix":"10.1002","volume":"9","author":[{"given":"Niloofar","family":"Tavangarrad","sequence":"first","affiliation":[{"name":"Avian Diseases Research Center Department of Clinical Sciences School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mosleh","sequence":"additional","affiliation":[{"name":"Avian Diseases Research Center Department of Clinical Sciences School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-7815","authenticated-orcid":false,"given":"Tahoora","family":"Shomali","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Department of Basic Sciences School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Namazi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maliheh","family":"Masoudian","sequence":"additional","affiliation":[{"name":"Molecular Department of Central Laboratory School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4265\/bio.17.93"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X261005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20170904"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.10.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.18.2.110.5375"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.4.378"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10060526"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000668"},{"issue":"7","key":"e_1_2_9_10_1","first-page":"776","article-title":"Topical ciprofloxacin for bacterial corneal ulcer","volume":"83","author":"Kosrirukvongs P.","year":"2000","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3201"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ICL.00000117255.97190.98"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1054"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108399"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.07.002"},{"issue":"3","key":"e_1_2_9_16_1","first-page":"188","article-title":"Deterioration of wound healing and intense suppression of MMP\u20109 mRNA expression after short\u2010term administration of different topical glucocorticoids or NSAIDs in an avian model of corneal lesions","volume":"22","author":"Mirarab Razi H.","year":"2021","journal-title":"Iranian Journal of Veterinary Research"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702303"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(97)80241-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.09.018"},{"issue":"4","key":"e_1_2_9_20_1","first-page":"260","article-title":"Complicated corneal ulcer. 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