{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:33:50Z","timestamp":1783438430415,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      One of the most common causes of pneumonia is\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      ). As with other microbial pathogens, this bacterium tends to develop resistance to various antibiotics. Amikacin and erythromycin, which are from the aminoglycoside and macrolide antibiotic families, are used to treat respiratory infections caused by\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study explored whether amikacin, erythromycin or a combination of both works better against\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      acute lung infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For this study, 32 rats were used. The trachea of rats was exposed aseptically and their lung was infected with\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      through trachea. Then, according to the group, they received amikacin, erythromycin or a combination of both for 1 week. Finally, they were euthanised on the 3rd and 7th days post\u2010infection. The macroscopic and microscopic evaluations of the lungs, kidney and liver were performed. The right lung was collected for in vivo bacteriological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The amikacin group (A group) had a statistically significantly lower macroscopic and microscopic scores than the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In vivo bacteriological test revealed that the A group had significantly lower lung bacterial load (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In summary, it was concluded that amikacin could help alleviate the respiratory infection caused by\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      solely, and it was more effective than erythromycin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.991","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:08:32Z","timestamp":1667304512000},"page":"867-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The comparative effects of erythromycin and amikacin on acute respiratory\n                    <i>Pseudomonas aeruginosa<\/i>\n                    infection"],"prefix":"10.1002","volume":"9","author":[{"given":"Mohsen","family":"Yazdanian","sequence":"first","affiliation":[{"name":"Research Center for Prevention of Oral and Dental Diseases Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-5383","authenticated-orcid":false,"given":"Peyman Esmaeili Fard","family":"Barzegar","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Clinical Sciences, Lorestan University Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Research Center for Prevention of Oral and Dental Diseases Baqiyatallah University of Medical Sciences Tehran Iran"},{"name":"School 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Farjanikish","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine Lorestan University Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.4.872"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9783-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201801-012OC"},{"key":"e_1_2_11_6_1","first-page":"4620","article-title":"Relation of microbial biomass to counting units for Pseudomonas aeruginosa","volume":"6","author":"Dong\u2010ju K.","year":"2012","journal-title":"African Journal of Microbiology 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