{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:49:39Z","timestamp":1789274979256,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record Open"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aetiology of increased mean platelet volume in dogs is currently uncertain. Our aim was to investigate the aetiology of increased mean platelet volume in dogs with and without thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The database of a teaching hospital was retrospectively searched for dogs with increased mean platelet volume (&gt;14.4\u00a0fL) over a 3\u2010year period. Complete blood counts were performed with an Advia 120 analyser. Cases with incomplete medical records or belonging to breeds known to be associated with macrothrombocytopenia were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six dogs were included, with Group 1 consisting of non\u2010thrombocytopenic dogs (49\/66, 74.2%) and Group 2 consisting of thrombocytopenic dogs (17\/66, 25.8%). Diagnoses significantly differed between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). In Group 1, inflammatory\/infectious diseases (69.4%) were the most common cause, followed by neoplastic diseases (8.2%) and diabetes mellitus (6.1%). Dogs in Group 2 were diagnosed with either inflammatory\/infectious diseases (50.0%) or neoplastic diseases (50.0%). The small sample size\u2010 and a potential delayed haematological analysis of some of the blood samples, could have artifactually affected the mean platelet volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In dogs with thrombocytopenia and increased mean platelet volume, inflammatory\/infectious or neoplastic diseases should be considered. In non\u2010thrombocytopenic dogs, increased mean platelet volume is primarily associated with inflammatory\/infectious diseases, with neoplasia and diabetes mellitus being infrequent causes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vro2.70000","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T05:36:13Z","timestamp":1733204173000},"source":"Crossref","is-referenced-by-count":1,"title":["A retrospective study of the aetiology of increased mean platelet volume in dogs presented to a small animal teaching hospital in Greece"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-9891","authenticated-orcid":false,"given":"Ioannis L.","family":"Oikonomidis","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"},{"name":"Department of Veterinary Anatomy, Physiology and Pathology Institute of Infection Veterinary and Ecological Sciences University of Liverpool, Wirral  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris","family":"Antoniadis","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Papathanasiou","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-0338","authenticated-orcid":false,"given":"Theodora K.","family":"Tsouloufi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"},{"name":"Department of Veterinary Anatomy, Physiology and Pathology Institute of Infection Veterinary and Ecological Sciences University of Liverpool, Wirral  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timokleia","family":"Kousi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rafaella","family":"Kalafati","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kritsepi\u2010Konstantinou","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2008.00636.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795049804"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.2.487.487"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.1974.tb00475.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.200.03.368"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.206.03.332"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/78.2.150"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2019.7732"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12405"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.8.960"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26674"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056\u20108727(02)00282\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.653391"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12628"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"TangPK MartinezC O'NeillE ShielRE.Evaluation of alterations in mean platelet volume in dogs with pancreatitis.British Small Animal ss 2019; abstract proceedings 2019.British Small Animal Veterinary Association;2019. p.476. 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