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In Algeria, data are very limited, making investigations quite relevant. This study aimed to determine risk factors associated with neonatal lamb mortality, describe gross and histopathological lesions on affected organs, and identify bacterial pathogens involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Thirty\u2010five sheep farms located in Constantine participated in this survey between February and December 2022. An epidemiological questionnaire was used to describe monitoring practices and to identify associated risk factors. Twenty\u2010two collected lamb corpses (immediate postmortem changes) underwent detailed postmortem examinations, including anatomopathological, histopathological and microbiological analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The recorded neonatal mortality rate was 5.74%. Statistical analysis revealed significant associations between mortality and factors such as soil and livestock building hygiene, as well as the breeding system used (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). The lungs, liver, kidneys and heart were the most affected organs. Causes of death included respiratory disorders, omphalitis with septicaemia, stillbirth, trauma and starvation\u2010hypothermia syndrome. From these organs, 218 bacterial strains were isolated, mainly Enterobacteriaceae (\n                      <jats:italic>Escherichia coli, Klebsiella pneumoniae, Providencia<\/jats:italic>\n                      spp.,\n                      <jats:italic>Citrobacter<\/jats:italic>\n                      spp.), causing primary infections, alongside non\u2010fermenting Gram\u2010negative bacilli (\n                      <jats:italic>Pseudomonas aeruginosa, Comamonas<\/jats:italic>\n                      spp.,\n                      <jats:italic>Acinetobacter<\/jats:italic>\n                      spp.), responsible for the associated septicaemic evolution. According to the EUCAST breakpoints, isolates were resistant to commonly used antibiotics: amoxicillin, amoxicillin\/clavulanic acid, trimethoprim\/sulfamethoxazole and tetracycline. Notably, only\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      spp. strains harboured\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>SHV<\/jats:sub>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study concluded that improved sanitary protocols, early diagnosis and antimicrobial testing are crucial to prevent neonatal mortality. It also recommended larger studies and farmer training programmes to enhance lambing and neonatal care practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vro2.70021","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:38:48Z","timestamp":1757777928000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological, pathological and microbiological investigation of neonatal lamb mortality in the region of Constantine, Algeria"],"prefix":"10.1002","volume":"12","author":[{"given":"Hayem","family":"Benmebarek","sequence":"first","affiliation":[{"name":"GSPA Research Laboratory (Management of Animal Health and Productions), Institute of Veterinary Sciences University Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Djeffal","sequence":"additional","affiliation":[{"name":"GSPA Research Laboratory (Management of Animal Health and Productions), Institute of Veterinary Sciences University Fr\u00e8res Mentouri  Constantine Algeria"},{"name":"Department of Agronomy University 20 Ao\u00fbt  Skikda Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louiza","family":"Benhamza","sequence":"additional","affiliation":[{"name":"GSPA Research Laboratory (Management of Animal Health and Productions), Institute of Veterinary Sciences University Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"GSPA Research Laboratory (Management of Animal Health and Productions), Institute of Veterinary Sciences University Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra","family":"Medjedoub","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (CRBT)  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha Adnane","family":"Smadi","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (CRBT)  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Boufendi","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (CRBT)  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Temime","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (CRBT)  Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Rolain","sequence":"additional","affiliation":[{"name":"APHM, MEPHI, IHU\u2010M\u00e9diterran\u00e9e Infection, Facult\u00e9 de Pharmacie Aix Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6466-2324","authenticated-orcid":false,"given":"Seydina M.","family":"Diene","sequence":"additional","affiliation":[{"name":"APHM, MEPHI, IHU\u2010M\u00e9diterran\u00e9e Infection, Facult\u00e9 de Pharmacie Aix Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"ChikhiZ.The future of sheep farming in Algeria: comprehensive analysis and proposed strategies.LinkedIn;2024. 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