{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:11:17Z","timestamp":1792681877615,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIRES Cognitive Science"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Healthy brain development takes place within the context of individual experience. Here, we describe how certain early experiences are necessary for typical brain development. We present evidence from multiple studies showing that severe early life neglect leads to alterations in brain development, which compromises emotional, behavioral, and cognitive functioning. We also show how early intervention can reverse some of the deleterious effects of neglect on brain development. We conclude by emphasizing that early interventions that start at the earliest possible point in human development are most likely to support maximal recovery from early adverse experiences. <jats:italic>WIREs Cogn Sci<\/jats:italic> 2017, 8:e1387. doi: 10.1002\/wcs.1387<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Psychology &gt; Development and Aging<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wcs.1387","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T15:08:41Z","timestamp":1480604921000},"source":"Crossref","is-referenced-by-count":49,"title":["Early experience and brain development"],"prefix":"10.1002","volume":"8","author":[{"given":"Johanna","family":"Bick","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston Children's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Children's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_7_1_2_1","unstructured":"Readers can refer to the following website for a list of related publications:http:\/\/www.bucharestearlyinterventionproject.org."},{"key":"e_1_2_7_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812474098"},{"key":"e_1_2_7_2_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1143921"},{"key":"e_1_2_7_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.025"},{"key":"e_1_2_7_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153822"},{"key":"e_1_2_7_2_6_1","doi-asserted-by":"publisher","DOI":"10.4159\/harvard.9780674726079"},{"key":"e_1_2_7_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.20108"},{"key":"e_1_2_7_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.20107"},{"key":"e_1_2_7_2_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579403000452"},{"key":"e_1_2_7_2_10_1","unstructured":"National Scientific Council on the Developing Child. 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