{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:07:10Z","timestamp":1791187630949,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Developmental Biology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The neural tube (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>), the embryonic precursor of the vertebrate brain and spinal cord, is generated by a complex and highly dynamic morphological process. In mammals, the initially flat neural plate bends and lifts bilaterally to generate the neural folds followed by fusion of the folds at the midline during the process of neural tube closure (<jats:styled-content style=\"fixed-case\">NTC<\/jats:styled-content>). Failures in any step of this process can lead to neural tube defects (<jats:styled-content style=\"fixed-case\">NTDs<\/jats:styled-content>), a common class of birth defects that occur in approximately 1 in 1000 live births. These severe birth abnormalities include <jats:italic>spina bifida<\/jats:italic>, a failure of closure at the spinal level; craniorachischisis, a failure of <jats:styled-content style=\"fixed-case\">NTC<\/jats:styled-content> along the entire body axis; and exencephaly, a failure of the cranial neural folds to close which leads to degeneration of the exposed brain tissue termed anencephaly. The mouse embryo presents excellent opportunities to explore the genetic basis of <jats:styled-content style=\"fixed-case\">NTC<\/jats:styled-content> in mammals; however, its <jats:italic>in utero<\/jats:italic> development has also presented great challenges in generating a deeper understanding of how gene function regulates the cell and tissue behaviors that drive this highly dynamic process. Recent technological advances are now allowing researchers to address these questions through visualization of <jats:styled-content style=\"fixed-case\">NTC<\/jats:styled-content> dynamics in the mouse embryo in real time, thus offering new insights into the morphogenesis of mammalian <jats:styled-content style=\"fixed-case\">NTC<\/jats:styled-content>. <jats:italic>WIREs Dev Biol<\/jats:italic> 2014, 3:59\u201368. doi: 10.1002\/wdev.120<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Early Embryonic Development &gt; Gastrulation and Neurulation<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nervous System Development &gt; Vertebrates: Regional Development<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Birth Defects &gt; Craniofacial and Nervous System Anomalies<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wdev.120","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T19:44:44Z","timestamp":1369856684000},"page":"59-68","source":"Crossref","is-referenced-by-count":32,"title":["Morphogenetic movements in the neural plate and neural tube: mouse"],"prefix":"10.1002","volume":"3","author":[{"given":"R'ada","family":"Massarwa","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics The Weizmann Institute of Science  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cell Biology Stem Cells and Development Graduate Program University of Colorado School of Medicine and Children's Hospital Colorado  Aurora CO 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