{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:14:48Z","timestamp":1792077288455,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NICHD","award":["T32HD007183"],"award-info":[{"award-number":["T32HD007183"]}]},{"name":"NIH","award":["DC005987"],"award-info":[{"award-number":["DC005987"]}]},{"name":"NIH","award":["DC011269"],"award-info":[{"award-number":["DC011269"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Developmental Biology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The zebrafish lateral line is a sensory system used to detect changes in water flow. It is comprised of clusters of mechanosensory hair cells called neuromasts. The lateral line is initially established by a migratory group of cells, called a primordium, that deposits neuromasts at stereotyped locations along the surface of the fish. Wnt, <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>, and Notch signaling are all important regulators of various aspects of lateral line development, from primordium migration to hair cell specification. As zebrafish age, the organization of the lateral line becomes more complex in order to accommodate the fish's increased size. This expansion is regulated by many of the same factors involved in the initial development. Furthermore, unlike mammalian hair cells, lateral line hair cells have the capacity to regenerate after damage. New hair cells arise from the proliferation and differentiation of surrounding support cells, and the molecular and cellular pathways regulating this are beginning to be elucidated. All in all, the zebrafish lateral line has proven to be an excellent model in which to study a diverse array of processes, including collective cell migration, cell polarity, cell fate, and regeneration. <jats:italic>WIREs Dev Biol<\/jats:italic> 2015, 4:1\u201316. doi: 10.1002\/wdev.160<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Nervous System Development &gt; Vertebrates: Regional Development<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Adult Stem Cells, Tissue Renewal, and Regeneration &gt; Regeneration<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wdev.160","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T09:49:23Z","timestamp":1415612963000},"page":"1-16","source":"Crossref","is-referenced-by-count":110,"title":["There and back again: development and regeneration of the zebrafish lateral line system"],"prefix":"10.1002","volume":"4","author":[{"given":"Eric D.","family":"Thomas","sequence":"first","affiliation":[{"name":"Graduate Program in Neurobiology and Behavior University of Washington  Seattle WA USA"},{"name":"Department of Biological Structure University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Biological Structure University of Washington  Seattle WA USA"},{"name":"Molecular and Cellular Biology Graduate Program University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale W.","family":"Hailey","sequence":"additional","affiliation":[{"name":"Department of Biological Structure University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Raible","sequence":"additional","affiliation":[{"name":"Graduate Program in Neurobiology and Behavior University of Washington  Seattle WA USA"},{"name":"Department of Biological Structure University of Washington  Seattle WA USA"},{"name":"Molecular and Cellular Biology Graduate Program University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1963.tb00654.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8851-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02978174"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900450106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900570307"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2720"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.39.073003.105049"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.01.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3948-11.2011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5137-09.2010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902330307"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252339399"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.02.019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.05.020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-23"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.10.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306282110"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909998107"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12635"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.046"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.10.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.025981"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156547"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.032102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.083253"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.101675"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.082271"},{"key":"e_1_2_8_29_1","first-page":"1042","article-title":"Mitotic patterns in the migrating lateral line cells of zebrafish embryos","volume":"238","author":"Laguerre L","year":"2009","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.10.022"},{"key":"e_1_2_8_31_1","first-page":"3163","article-title":"Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish","volume":"239","author":"Gamba L","year":"2010","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.062554"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.062695"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091348"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02734"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00308-2"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.052761"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608536103"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.07.018"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2009.00346.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.060566"},{"key":"e_1_2_8_42_1","first-page":"387","article-title":"Neuronal differences prefigure somatotopy in the zebrafish lateral line","volume":"128","author":"Gompel N","year":"2001","journal-title":"Dev Camb Engl"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000529)421:2<189::AID-CNE5>3.0.CO;2-K"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004477"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2425-08.2008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912082106"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.047316"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7558"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2009.0995"},{"key":"e_1_2_8_50_1","first-page":"1919","article-title":"Progressive neurogenesis defines lateralis somatotopy","volume":"239","author":"Pujol\u2010Mart\u00ed J","year":"2010","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5157-11.2012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1235"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0145"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002171107"},{"key":"e_1_2_8_55_1","first-page":"2058","article-title":"Single\u2010cell analysis of somatotopic map formation in the zebrafish lateral line system","volume":"239","author":"Sato A","year":"2010","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4568-12.2013"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22798"},{"key":"e_1_2_8_58_1","first-page":"597","article-title":"Postembryonic development of the posterior lateral line in zebrafish","volume":"129","author":"Ledent V","year":"2002","journal-title":"Dev Camb Engl"},{"key":"e_1_2_8_59_1","first-page":"605","article-title":"Cell migration in the postembryonic development of the fish lateral line","volume":"129","author":"Sap\u00e8de D","year":"2002","journal-title":"Dev Camb Engl"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.02.017"},{"key":"e_1_2_8_61_1","first-page":"370","article-title":"Postembryonic development of the cranial lateral line canals and neuromasts in zebrafish","volume":"228","author":"Webb JF","year":"2003","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.05.004"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.07.005"},{"key":"e_1_2_8_64_1","first-page":"2889","article-title":"Development of diverse lateral line patterns on the teleost caudal fin","volume":"237","author":"Wada H","year":"2008","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.020"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01832"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214004110"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.06.035"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-002-3022-x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00039-3"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2007.07.003"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.05.005"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.08.004"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.10.015"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1897\/05-241R.1"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20386"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4372-07.2008"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2009.0048"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029727"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.2012570"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047257"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3905-11.2012"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000455"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-12-6"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.04.013.2009"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-120"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402898111"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318692111"},{"key":"e_1_2_8_89_1","first-page":"832","article-title":"Activation of canonical Wnt\/\u03b2\u2010catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line","volume":"242","author":"Head JR","year":"2013","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5785-10.2012"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00047"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2012.00529.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.02.016"}],"container-title":["WIREs Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwdev.160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwdev.160","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wdev.160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:56:14Z","timestamp":1695718574000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wdev.160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/wdev.160"],"URL":"https:\/\/doi.org\/10.1002\/wdev.160","archive":["Portico"],"relation":{},"ISSN":["1759-7684","1759-7692"],"issn-type":[{"value":"1759-7684","type":"print"},{"value":"1759-7692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}