{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:07Z","timestamp":1786978567429,"version":"build-2736575974"},"reference-count":93,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007795","name":"Stowers Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE 016082"],"award-info":[{"award-number":["DE 016082"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["105610"],"award-info":[{"award-number":["105610"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Developmental Biology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    Craniofacial anomalies account for approximately one\u2010third of all congenital birth defects reflecting the complexity of head and facial development. Craniofacial development is dependent upon a multipotent, migratory population of neural crest cells, which generate most of the bone and cartilage of the head and face. In this review, we discuss advances in our understanding of the pathogenesis of a specific array of craniofacial anomalies, termed facial dysostoses, which can be subdivided into mandibulofacial dysostosis, which present with craniofacial defects only, and acrofacial dysostosis, which encompasses both craniofacial and limb anomalies. In particular, we focus on Treacher Collins syndrome, Acrofacial Dysostosis\u2010Cincinnati Type as well as Nager and Miller syndromes, and animal models that provide new insights into the molecular and cellular basis of these congenital syndromes. We emphasize the etiologic and pathogenetic similarities between these birth defects, specifically their unique deficiencies in global processes including ribosome biogenesis,\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage repair, and pre\u2010\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    splicing, all of which affect neural crest cell development and result in similar tissue\u2010specific defects.\n                    <jats:italic>WIREs Dev Biol<\/jats:italic>\n                    2017, 6:e263. doi: 10.1002\/wdev.263\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>Signaling Pathways &gt; Cell Fate Signaling<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Birth Defects &gt; Craniofacial and Nervous System Anomalies<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wdev.263","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T07:57:00Z","timestamp":1486713420000},"source":"Crossref","is-referenced-by-count":36,"title":["Rare syndromes of the head and face: mandibulofacial and acrofacial dysostoses"],"prefix":"10.1002","volume":"6","author":[{"given":"Karla","family":"Terrazas","sequence":"first","affiliation":[{"name":"Stowers Institute for Medical Research  Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Dixon","sequence":"additional","affiliation":[{"name":"Division of Dentistry, Faculty of Biology, Medicine &amp; Health, Manchester Academic Health Sciences Centre, Michael 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