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As this pandemic spreads, rapid scientific investigation is shedding new light on how prenatal infection with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> causes microcephaly. In this analysis we provide an overview of both microcephaly and <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>, explore the connection between prenatal <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection and microcephaly, and highlight recent insights into how prenatal <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection depletes the pool of neural progenitors in the developing brain. <jats:italic>WIREs Dev Biol<\/jats:italic> 2017, 6:e273. doi: 10.1002\/wdev.273<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Nervous System Development &gt; Vertebrates: General Principles<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Birth Defects &gt; Craniofacial and Nervous System Anomalies<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Adult Stem Cells, Tissue Renewal, and Regeneration &gt; Stem Cells and 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