{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:00Z","timestamp":1792174740509,"version":"4.4.0"},"reference-count":135,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["3R01EY025794\u201001A1S1"],"award-info":[{"award-number":["3R01EY025794\u201001A1S1"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1RO1EY025794\u201001A1"],"award-info":[{"award-number":["1RO1EY025794\u201001A1"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Developmental Biology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    The cornea is our window to the world and our vision is critically dependent on corneal clarity and integrity. Its epithelium represents one of the most rapidly regenerating mammalian tissues, undergoing full\u2010turnover over the course of approximately 1\u20132\u2009weeks. This robust and efficient regenerative capacity is dependent on the function of stem cells residing in the limbus, a structure marking the border between the cornea and the conjunctiva. Limbal stem cells (LSC) represent a quiescent cell population with proliferative capacity residing in the basal epithelial layer of the limbus within a cellular niche. In addition to LSC, this niche consists of various cell populations such as limbal stromal fibroblasts, melanocytes and immune cells as well as a basement membrane, all of which are essential for LSC maintenance and LSC\u2010driven regeneration. The LSC niche's components are of diverse developmental origin, a fact that had, until recently, prevented precise identification of molecularly defined LSC. The recent success in prospective LSC isolation based on ABCB5 expression and the capacity of this LSC population for long\u2010term corneal restoration following transplantation in preclinical\n                    <jats:italic>in vivo<\/jats:italic>\n                    models of LSC deficiency underline the considerable potential of pure LSC formulations for clinical therapy. Additional studies, including genetic lineage tracing of the developmental origin of LSC will further improve our understanding of this critical cell population and its niche, with important implications for regenerative medicine.\n                    <jats:italic>WIREs Dev Biol<\/jats:italic>\n                    2018, 7:e303. doi: 10.1002\/wdev.303\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>Adult Stem Cells, Tissue Renewal, and Regeneration &gt; Stem Cells and Disease<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Adult Stem Cells, Tissue Renewal, and Regeneration &gt; Tissue Stem Cells and Niches<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Adult Stem Cells, Tissue Renewal, and Regeneration &gt; Regeneration<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wdev.303","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T13:41:17Z","timestamp":1509716477000},"source":"Crossref","is-referenced-by-count":120,"title":["Limbal stem cells: identity, developmental origin, and therapeutic potential"],"prefix":"10.1002","volume":"7","author":[{"given":"Gabriel","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Medicine VA Boston Healthcare System Boston MA USA"},{"name":"Division of Genetics, Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuru","family":"Sasamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine VA Boston Healthcare System Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Ksander","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear, Schepens Eye Research Institute Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus H.","family":"Frank","sequence":"additional","affiliation":[{"name":"Transplant Research Program, Boston Children's Hospital Harvard Medical School Boston MA USA"},{"name":"Harvard Stem Cell Institute Harvard University Cambridge MA USA"},{"name":"School of Medical and Health Sciences Edith Cowan University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Y.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Medicine VA Boston Healthcare System Boston MA USA"},{"name":"Division of Genetics, Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/229560a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.1.49"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1989.22"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.19.2867"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90958-6"},{"key":"e_1_2_6_7_1","first-page":"1533","article-title":"Comparison of limbal and peripheral human corneal epithelium in tissue culture","volume":"29","author":"Ebato B","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_8_1","first-page":"1864","article-title":"Relative proliferative rates of limbal and corneal epithelia. 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