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At loading hydrophobic nano\u2010SiO<jats:sub>2<\/jats:sub> particle concentration (0.50\u20131.50\u2009wt.%), the developed nanocomposite membranes are optimized in terms of vacuum membrane distillation performance. The influence of temperature, vacuum pressure, and feed water flow is studied for desalinating high\u2010salinity brine. The results show that the developed vacuum distillation membrane is capable of 95% salt rejection during the treatment of a highly saline feed (65,000\u2009ppm) at fixed flow rates of 120\u00a0L\/h saline feed and different operating conditions consisting of feed inlet temperatures ranging from 40\u00b0C to 70\u00b0C and distillate inlet temperatures of 7\u201315\u00b0C. The vacuum membrane distillation process achieves 0.38\u20131.66% water recovery with increasing concentration factor, meaning that recovery is increased, and shows a specific electrical energy consumption of 5.16\u201323.90 kWh\/m<jats:sup>3<\/jats:sup> for product water. Overall, the newly designed membrane demonstrates suitability for a vacuum membrane distillation system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Practitioner Points<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Desalinate high\u2010salinity brine (TDS\u2009&gt;\u200935,000\u2009ppm) using a vacuum membrane distillation system.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A hydrophobic PVDF\u2010HFP\/SiO<jats:sub>2<\/jats:sub> nanocomposite membrane development for vacuum membrane distillation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A newly designed single vacuum membrane distillation system for RO brine treatment.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/wer.10980","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T03:36:50Z","timestamp":1706153810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Performance investigation of poly(vinylidene fluoride\u2010cohexafluoropropylene) membranes containing SiO<sub>2<\/sub> nanoparticles in a newly designed single vacuum membrane distillation system"],"prefix":"10.1002","volume":"96","author":[{"given":"Turki","family":"Hussain mana","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, College of Engineering King Saud University  Riyadh Saudi Arabia"},{"name":"Desalination Technologies Institute King Abdulaziz City for Science and Technology (KACST)  Riyadh Saudi 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