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These compounds, known for their ability to transport cations across biological membranes, are crucial in maintaining cellular homeostasis. However, their extensive use raises environmental and human health concerns. This manuscript offers a comprehensive review of ionophores in livestock production, highlighting their environmental impact and potential to contribute to antimicrobial resistance (AMR). It emphasizes the fate and transport of ionophores in various environmental matrices, providing a holistic framework for assessing ecological risks. The study calls for improved management practices like enhanced waste management through anaerobic digestion, and composting is essential. Establishing Maximum Residue Limits (MRLs) and using LC\u2013MS\/MS for residue detection will help manage exposure. Educating livestock producers and researching alternatives like probiotics can decrease reliance on ionophores to mitigate the ecological footprint of ionophores, making it a timely and relevant piece of research. Ionophores can persist in the environment, potentially contributing to AMR in gram\u2010positive bacteria. Furthermore, their presence in manure, runoff, and agricultural soils has been documented, leading to contamination of water bodies and sediments. Ionophores pose risks to terrestrial and aquatic ecosystems, with studies revealing hazardous effects even at low concentrations. This review highlights the need for improved management practices to mitigate the environmental impacts of ionophores, particularly regarding AMR development and ecosystem disruption. Careful monitoring and sustainable use of these antibiotics are essential to reduce their ecological footprint in livestock production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Practitioner Points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Ionophores enhance feed efficiency, but pose environmental health risks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Their persistence may lead to antimicrobial resistance in gram\u2010positive bacteria.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ionophore contamination threatens both terrestrial and aquatic ecosystems.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Monitoring and management are crucial to mitigate ionophore\u2010related risks.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/wer.70052","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:52:24Z","timestamp":1741769544000},"page":"1-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ecological footprint of ionophores in livestock production: Environmental pathways and effects"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-4336","authenticated-orcid":false,"given":"Mahbub","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Environmental Science Bangladesh University of Professionals (BUP)  Dhaka Bangladesh"},{"name":"Department of Environmental Health Sciences, Arnold School of Public Health University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Samium","family":"Basir","sequence":"additional","affiliation":[{"name":"Department of Environmental Science Bangladesh University of Professionals (BUP)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisha Binte","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Environmental Science Bangladesh University of Professionals (BUP)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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