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Unlike oral mucositis during or after radiotherapy, radiation\u2010induced sinusitis is easily overlooked in clinical practice and rarely included in experimental studies. Herein, we review the literature to date on radiation\u2010induced rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant studies published between 1995 and 2022 were determined through a detailed search using open keywords from PubMed, with manual search of the reference list of the identified articles. Keywords searched were \u201cionizing radiation,\u201d \u201cradiotherapy,\u201d \u201cintensity\u2010modulated radiotherapy,\u201d \u201chead and neck tumor,\u201d \u201cnasopharyngeal carcinoma,\u201d \u201cnasal epithelium,\u201d \u201cradiation damage,\u201d and \u201cradiation\u2010induced rhinosinusitis.\u201d Full\u2010text articles that clearly stated the pathogenesis, clinical manifestation, predictors, treatment, and prognosis of radiation\u2010induced rhinosinusitis were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Radiation\u2010induced rhinosinusitis occurs during radiotherapy and can last for months or even years after radiotherapy. A mixture of cellular outcomes caused by ionizing radiation and persistent damage of the epithelial and submucosal tissues after the treatment result from the radiotherapy itself. Endoscopic sinus surgery improves symptoms but can be accompanied by intraoperative and postoperative complications. Nasal irrigation, steroids, and antibiotics appear to reduce inflammation and relieve symptoms to a certain extent. Studies on other potentially useful drugs are underway and in the exploration stage, without clinical application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite its high incidence, radiation\u2010induced rhinosinusitis is a type of dose\u2010limiting toxicity that theoretically does not produce fatal effects at controlled doses and with adequate follow\u2010up care. In moderate\u2010to\u2010severe cases, toxicity may be present. Currently, radiation\u2010induced rhinosinusitis has potential prevention and treatment strategies. However, no unified management protocol has shown significant improvement in radiation\u2010induced rhinosinusitis. Further research is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjo2.134","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:25:53Z","timestamp":1693812353000},"page":"324-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radiation\u2010induced rhinosinusitis: Mechanism research and clinical progress review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-2582","authenticated-orcid":false,"given":"Chunge","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-5182","authenticated-orcid":false,"given":"Longgang","family":"Yu","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head 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