{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:22Z","timestamp":1786978702498,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasopharyngeal tissue hyperplasia is generally associated with adenoids in childhood. In adults, nasopharyngeal masses are occasionally found, but data on symptoms, clinical findings, and histologic results are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A 10\u2010year retrospective study was conducted, analyzing data from adult patients who underwent nasopharyngeal biopsies. The study included information on case history, preoperative suspected diagnosis, and histology type. Statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and fifty\u2010five patients were included, most of them complaining of nasal obstruction, ear pressure, and hearing loss. Biopsy revealed adenoid tissue (64.7%), solid malignancies (15.7%; dominant undifferentiated carcinoma), lymphomas (9.0%), cysts (7.8%), and other benign tumors (2.7%). Malignant neoplasms were predominantly found in male and in elderly patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). If a malignant tumor was suspected initially, histological examination confirmed this in 75% of the cases. 45% of patients with a malignant nasopharyngeal mass had a unilateral seromucous tympanum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Persistent nasopharyngeal masses in adults\u2014particularly in elderly men, smokers and those with simultaneous unilateral seromucous tympanum\u2014should undergo a histological examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjo2.139","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:56:06Z","timestamp":1698713766000},"page":"45-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nasopharyngeal masses in adults\u2014A retrospective analysis of 255 patients to evaluate symptoms, clinical findings, and histological results"],"prefix":"10.1002","volume":"11","author":[{"given":"Melanie M.","family":"von Witzleben","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"von Witzleben","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-7118","authenticated-orcid":false,"given":"Janina","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004559"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"S13","article-title":"The adenoid: its history and a cautionary tale","volume":"127","author":"Ruben RJ","year":"2017","journal-title":"Laryngoscope"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"RaccaJM LeeJ SikorskiF Crenshaw3rdEB HoodLJCholesteatoma is associated with pediatric progressive sensorineural hearing loss.Ear Hear.2022;43:1282\u20101290.","DOI":"10.1097\/AUD.0000000000001176"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2020.06.200038"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0787-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24696"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-008-1762-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1702"},{"key":"e_1_2_11_13_1","first-page":"581","article-title":"Epstein\u2010Barr virus and nasopharyngeal carcinoma","volume":"33","author":"Young LS","year":"2014","journal-title":"Chin J Cancer"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29670"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106000685"},{"key":"e_1_2_11_16_1","first-page":"279","article-title":"Eight years of clinical findings and biopsy results of nasopharyngeal pathologies in 1647 adult patients: a retrospective study","volume":"10","author":"Berkiten G","year":"2014","journal-title":"B\u2010ENT"}],"container-title":["World Journal of Otorhinolaryngology - Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjo2.139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:47:29Z","timestamp":1741693649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjo2.139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,30]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/wjo2.139"],"URL":"https:\/\/doi.org\/10.1002\/wjo2.139","archive":["Portico"],"relation":{},"ISSN":["2095-8811","2589-1081"],"issn-type":[{"value":"2095-8811","type":"print"},{"value":"2589-1081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,30]]},"assertion":[{"value":"2023-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}