{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:46:52Z","timestamp":1782838012727,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) virus in the early phases of the COVID\u201019 pandemic. In most COVID\u201019 patients, olfaction recovers over the course of a few weeks. However, a lasting partial or complete loss of smell, often associated with distorted olfactory perceptions termed parosmia, has emerged as a widespread problem impacting at least 5%\u201310% of those who experience anosmia due to COVID\u201019. Our inability to offer effective therapies to this hyposmic or anosmic population, comprising millions of patients, highlights an enormous unmet need for the medical system. Here, we summarize the current understanding of the pathobiology causing acute olfactory loss due to SARS\u2010CoV\u20102 infection, focusing on how the virus interacts with the peripheral olfactory system, a major site of viral infection. We also explore the problem of long\u2010COVID olfactory dysfunction, which may accompany other persistent systemic disorders collectively termed postacute sequelae of COVID\u201019. Specifically, we discuss an emerging model focused on unresolved immune cell activity driving ongoing dysfunction. Finally, we review current and future therapeutic approaches aimed at restoring olfactory function.<\/jats:p>","DOI":"10.1002\/wjo2.165","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T07:45:11Z","timestamp":1711007111000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term olfactory loss post\u2010COVID\u201019: Pathobiology and potential therapeutic strategies"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1077-7298","authenticated-orcid":false,"given":"Sarah","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-1276","authenticated-orcid":false,"given":"John 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