{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:18:18Z","timestamp":1740176298597,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32DC000022"],"award-info":[{"award-number":["T32DC000022"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World j. otorhinolaryngol.-head neck surg."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To share a single institutional experience with clinical research on COVID\u2010related olfactory dysfunction (OD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Source\/Method<\/jats:title><jats:p>Narrative review of published original data and ongoing clinical trials on COVID\u2010related OD at Washington University from 2020 to 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were three new diagnostic\u2010\/patient\u2010reported outcome measures developed and tested. We report five clinical trials of interventions for COVID\u2010related olfactory disorders: combined Visual\u2010Olfactory Training (VOLT) with patient\u2010preferred scents versus standard olfactory training (<jats:italic>VOLT trial<\/jats:italic>), oral gabapentin versus placebo (<jats:italic>Gabapentin for the Relief of Acquired Chemosensory Experience trial<\/jats:italic>), nasal theophylline irrigations versus placebo (<jats:italic>Smell Changes and Efficacy of Nasal Theophylline trial<\/jats:italic>), stellate ganglion block (single\u2010arm), and mindfulness\u2010based stress reduction (MBSR) versus lifestyle intervention <jats:italic>(MBSR trial)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initial intervention trials for COVID\u2010related OD have shown potential for improving subjective and objective olfactory outcomes. However, there remains no gold standard treatment that definitively outperforms placebo in controlled trials. Therefore, continued investigation of novel therapeutic strategies for COVID\u2010related OD is necessary to maximize olfactory outcomes for affected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/wjo2.176","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T07:40:43Z","timestamp":1713512443000},"page":"129-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical studies in COVID\u2010related olfactory disorders: Review of an institutional experience"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-2343","authenticated-orcid":false,"given":"Theresa","family":"Tharakan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Clinical Outcomes Research Office, School of Medicine Washington University in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Clinical Outcomes Research Office, School of Medicine Washington University in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay F.","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Clinical Outcomes Research Office, School of Medicine Washington University in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Prognosis and persistence of smell and taste dysfunction in patients with covid\u201019: meta\u2010analysis with parametric cure modelling of recovery curves","volume":"378","author":"Tan BKJ","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2023.01.041"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103572"},{"issue":"31","key":"e_1_2_11_5_1","first-page":"1","article-title":"Position paper on olfactory dysfunction: 2023","volume":"61","author":"Whitcroft KL","year":"2023","journal-title":"Rhinology"},{"key":"e_1_2_11_6_1","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner J","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.3994"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3299"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.4112"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.1573"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103299"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.477"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22135"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16942"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-022-01528-y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23117"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00702-X"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v31i2.3366"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v31i2.3367"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181914a97"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaoto.342"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.810"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.1574"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830818"},{"volume-title":". 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